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Sero-Prevalence and Risk Factors for HDV Infection Among HIV/HBV Co-Infected Patients in Sokoto North Western Nigeria

Abdulmumini Yakubu
2019 Texila international journal of public health  
Hepatitis D virus infection may worsen HBV infection and about 5 % of HBV infected individuals may be infected with HDV infection as these viruses have similar routes of transmission. Severity of HBV infection is worsen by HIV co-infection. Therefore, this study aimed at the determination of prevalence and risk factors of HDV infection among HIV/HBV Co-infected individuals. Methods: This was cross sectional study in which treatment-naïve HIV infected study participants were screened for HBs Ag.
more » ... creened for HBs Ag. Study participants that were positive for HBs Ag were further screened for anti HDV and HBe Ag and also, they were assessed for CD4 + T lymphocytes count, ALT and AST levels. SPSS version 20 was used for the statistical analysis and level of significance was considered at p ≤ 0.05. Results: About 4(10.8 %) of 37 HIV/HBV co-infected study were positive for anti HDV. There was no statistical association of HDV infection with different tested variables, though numerically higher among females (P≤ 0.587), 41-50 years age group (P≤ 0.671), subjects with history of multiple sexual partners (P≤ 0.557), blood transfusion (p ≤ 0.298) and needle sharing (P ≤ 0.456). Mean ALT and AST levels, mean CD4 + T cell counts and HBe Ag prevalence were comparable between anti HDV positive and negative study participants with HIV/HBV co-infection. Conclusion: Substantial number of HIV/HBV co-infected study participants were observed to be infected with HDV infection. We recommend the screening of HDV infection among HIV/HBV co-infected individuals to ensure their proper management.
doi:10.21522/tijph.2013.07.01.art001 fatcat:3ydlxsqbmjbfbi55ztjnsrrcb4