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SERUM LIPID PEROXIDATION AND ANTIOXIDANT STATUS IN WOMAN WITH PREGNANCY INDUCED HYPERTENSION

V Breetha, Dr Lavanya Kumari, S Sethupathiy
2016 unpublished
AIM: Pregnancy-induced hypertension (PIH) is a common medical complication of pregnancy with a high incidence. Oxidative stress is one of the important factor in the etiopathogenisis of PIH. So this study is design ed to evaluate the serum lipid peroxidation and antioxidant status in women with pregnancy induced hypertension and healthy pregnant women in third trimester. METHODS: This is a Case control study comprised of 50 healthy pregnant women and 50 PIH cases in their third trimester of
more » ... rd trimester of pregnancy. Serum Malondialdehyde level (MDA), and ferric reducing ability of plasma (FRAP) were estimated in all these cases in their third trimester of pregnancy. RESULTS: There was a significantly higher Serum Malondialdehyde levels (MDA) and lower FRAP levels in PIH (P=<0.001), as compared to healthy pregnant women. CONCLUSION: Elevated serum malondialdehyde (MDA) and lowered ferric reducing ability of plasma (FRAP) status in women with pregnancy induced hypertension in third trimester. It indicates that there is elevated oxidative stress in PIH patients which may contribute to the complications of PIH, but further studies are required to assess the influence of the oxidative stress on the outcome of the PIH. Early detection of these parameters are going to aid in better management of PIH cases. Keywords: pregnancy-induced hypertension (PIH), FRAP (ferric reducing ability of plasma), malondialdehyde (MDA), oxidative stress.
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