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A simple robust optimizer has been developed that can produce patientspecific calibration curves to convert x-ray computed tomography (CT) numbers to relative stopping powers (HU-RSPs) for proton therapy treatment planning. The difference between a digitally reconstructed radiograph waterequivalent path length (DRR WEPL ) map through the x-ray CT dataset and a proton radiograph (set as the ground truth) is minimized by optimizing the HU-RSP calibration curve. The function of the optimizer isdoi:10.1088/0031-9155/60/5/1901 pmid:25668437 fatcat:eidzpsqfdzd53j7zuuypfvjxgi