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Obesity affects graft function but not graft loss in kidney transplant recipients

Maria Irene Bellini, Kostas Koutroutsos, Hannah Nananpragasam, Emily Deurloo, Jack Galliford, Paul Elliot Herbert
2020 Journal of International Medical Research  
Objective: This study was performed to examine the suitability of transplantation in kidney transplant recipients (KTRs) with a high body mass index (BMI). Methods: In total, 370 consecutive KTRs stratified according to the World Health Organization BMI categories were retrospectively analysed. The estimated glomerular filtration rate (eGFR) was used to assess allograft function. Results: The mean BMI was 26.2 kg/m 2 . Among all patients, 148 (40.0%) were pre-obese, 47 (12.7%) were class I
more » ... ) were class I obese, 11 (3.0%) were class II obese, and 9 (2.4%) were class III obese. A linear trend for male sex and younger age was observed from the normal BMI group through the progressively higher groups. Overweight and obese KTRs had a significantly higher incidence of pre-transplant diabetes, but there was no difference in post-transplant new-onset hyperglycaemia. Obesity was not a significant risk factor for a lower eGFR at the 1-year follow-up, but it became significant at the 2-and 3-year follow-ups. Graft loss occurred in 28 patients, and 25 patients died during follow-up. No difference in all-cause allograft loss was found among the different BMI groups during follow-up. Conclusion: Obesity affects the eGFR in the long term. Allograft survival was lower, but not significantly.
doi:10.1177/0300060519895139 pmid:31939322 fatcat:z5nn7v3jvzfs7gwbdcufcgu2gi