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Background-The molecular pathways that control the wound healing after myocardial infarction (MI) are not completely elucidated. One of these pathways is the Wnt/Frizzled pathway. In this study, we evaluated Frizzled as a novel therapeutic target for MI. These Frizzled proteins act as receptors for Wnt proteins and were previously shown to be expressed in the healing infarct. Methods and Results-Wnt/Frizzled signaling has been studied for decades, but synthetic ligands that interfere with thedoi:10.1161/circulationaha.110.976969 pmid:21931076 fatcat:zlc4xspzlffz3ca3fpqaasu74e