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Spontaneous cell cycle synchronisation

Roger Highmore
2017 Figshare  
We suggest that it may be possible for the cell cycles of neighboring biological cells to become spontaneously synchronized, e.g., in the presence of defects or disease. We are not proposing that spontaneous synchronization of cycles between neighboring cells is necessarily common or permanent. Rather, we suggest that temporary islands or "domains" of cells with synchronized cell cycles can form and exhibit collective behavior for some time, before disappearing. We suggest that a cell with
more » ... at a cell with faulty DNA whose cycle is synchronized with those of surrounding healthy cells may be dragged past the G1/S and G2/M checkpoints even if, in isolation, it would be stalled to allow repair or marking for apoptosis.
doi:10.6084/m9.figshare.4989719.v1 fatcat:j4aqkjj7z5bi7gqnrdhsfybq5q