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TMSCl-Catalyzed synthesis of substituted quinolines from arylimines and enolizable aldehydes

2008 ARKIVOC  
Some substituted quinolines were effectively synthesized utilizing chlorotrimethylsilane (TMSCl) as efficient promoter in the cyclization addition of enolizable aldehydes to arylimines under an air atmosphere in DMSO. The clean, mild and ecofriendly process with high yields and a simple workup of the desired compounds are attractive features of the reaction which enables a facile preparation of the quinoline ring.
doi:10.3998/ark.5550190.0009.e06 fatcat:yz3dq62rdbdidgh7acuzp3edge