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Modeling HIV infection and therapies in humanized mice

M Nischang, G Gers-Huber, A Audigé, R Akkina, RF Speck
2012 Swiss Medical Weekly  
The human immunodeficiency virus (HIV) type-1 is a human-specific virus. The lack of a widely available small-animal model has seriously hampered HIV research. In 2004, a new humanised mouse model was reported. It was based on the intrahepatic injection of human CD34+ cord blood cells into newborn, highly immunodeficient mice. These mice develop a lymphoid system of human origin and are highly susceptible to HIV infection and showed disseminated infection, persistent viraemia and characteristic
more » ... and characteristic helper CD4+ T-cell loss. Here, we will briefly review the various existing humanised mouse models and highlight their value to the study of HIV infection. Summary The human immunodeficiency virus (HIV) type-1 is a human-specific virus. The lack of a widely available smallanimal model has seriously hampered HIV research. In 2004, a new humanised mouse model was reported. It was based on the intrahepatic injection of human CD34+ cord blood cells into newborn, highly immunodeficient mice. These mice develop a lymphoid system of human origin and are highly susceptible to HIV infection and showed disseminated infection, persistent viraemia and characteristic helper CD4+ T-cell loss. Here, we will briefly review the various existing humanised mouse models and highlight their value to the study of HIV infection.
doi:10.4414/smw.2012.13618 pmid:22777836 fatcat:azsrt6g22jh65ejjo7jqweixwa