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This Handbook brings together and describes the SIENNA project's theoretical and methodological approaches for ethical, legal and human rights analyses, societal acceptance and awareness studies, development of research ethics protocols and professional ethical codes. This Handbook is a reference source for work packages 2 (genomics), 3 (human enhancement) 4 (AI and robotics), and 5 (the consortium's proposals), and it will help to ensure theoretical coherence and methodological consistency.doi:10.5281/zenodo.4247384 fatcat:upfwytnrargo7p7b5smi4lvdum