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Trazodone hydrochloride has not been previously investigated and reported for potential administration through transdermal route. Therefore, the present investigation was carried out to study the effect of polymeric composition, drug content and plasticizer on the permeation of trazodone hydrochloride across the mouse epidermis for the development of transdermal therapeutic system. The pseudolatex films with different combination of polymers, plasticizer and drug were prepared from aqueousdoi:10.4103/0250-474x.22962 fatcat:nhuyhnxkorcs3pj2v4rksemtva