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Serum levels of vitamin D and chronic periodontitis in patients with chronic kidney disease

Jessica do Amaral Bastos, Luiz Carlos Ferreira de Andrade, Ana Paula Ferreira, Erica de Almeida Barroso, Patrícia de Castro Daibert, Patrícia Lima de Sá Barreto, Eduardo Machado Vilela, Andrea Marcia Marcaccini, Fernando Antonio Basile Colugnati, Marcus Gomes Bastos
2013 Brazilian Journal of Nephrology  
Concomitance of chronic periodontitis (CP) in patients with chronic kidney disease (CKD) have been associated with adverse outcomes. Vitamin D (25(OH)D) deficiency my play a role in CP and inadequate vitamin D status is common among patients with CKD. Objective: To examine the relationship between vitamin 25(OH) D and CP in patients with CKD not yet on dialysis. Methods: A case-control study was conducted. Cases and controls were defined as patients with CKD with and without CP, respectively.
more » ... CP, respectively. The demographic, clinical and laboratory data were obtained when the patient was attended in the outpatient clinic. CKD was defined and staged according to the NKF QDOKI TM . Serum 25(OH)D levels were measured by chemiluminescence when assessing the CP, which was definined according to the American Academy of Periodontoly (1999). Serum 25(OH)D levels were stratified into deficient (≤ 14 ƞg/mL), insufficient (15-29 ƞg/mL) and sufficiency (≥ 30 ƞg/mL). Results: A total of 15 cases were compared with 14 controls. Cases had lower median 25(OH) D levels than controls (22.6 versus 28.6 ƞg/mL, p < 0.01) and were more likely to be categorized as vitamin D insufficiency/deficiency (93,3% versus 57,1%, p < 0,004). On the other hand, the percentage of controls with vitamin D sufficiency was higher then cases (42,9% versus 6,7%, p < 0,004). Conclusion: In patients with CKD not yet on dialysis, vitamin D deficiency is associated with CP. AbstrAct Keywords: chronic periodontitis, renal insufficiency, chronic, vitamin D.
doi:10.5935/01012800.20130004 pmid:23598748 fatcat:ed65gykv7zbntaci26ehqjsn5m