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MicroRNA regulatory mechanisms in atherosclerosis

Ilgiz F. Gareev, Ozal Beylerli, A. B. Alyshov
2020 Vestnik severo-zapadnogo gosudarstvennogo medicinskogo universiteta im. I.I. Mečnikova  
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by a change in the intima of the arteries in the form of focal lipid deposits and the formation of a fibrous lid. Atherosclerosis is considered as the main cause of myocardial infarction, ischemic stroke and chronic lower limb ischemia. The pathogenesis of atherosclerosis is complex, and genetic mechanisms of atherosclerosis have not been fully investigated. The recent studies have shown that microRNAs
more » ... t microRNAs (miRNAs) can play a role in the development of atherosclerosis. MiRNAs are short, non-coding RNA molecules 1822 nucleotides in length that suppress gene expression at the post-transcriptional level by binding to the 3ʹ-untranslated region of mRNA targets. MiRNAs are involved in virtually all biological processes, including cell proliferation, apoptosis, and cell differentiation. MiRNAs control aging and dysfunction of endothelial cells, proliferation and migration of vascular smooth muscle cells, as well as cytokine synthesis and polarization of macrophages. In this paper, we focus on how miRNAs can influence the pathogenesis of atherosclerosis.
doi:10.17816/mechnikov202012111-20 fatcat:amxrtpxkznfzzk5xty5w7xzoie