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EFFECT OF CLOMIPRAMINE PRETREATMENT ON SODIUM VALPROATE, DEXFENFLURAMINE AND 5-HYDROXYTRYPTAMINE INDUCED WET DOG SHAKE BEHAVIOR IN RATS

Research Article, B Sattigeri, J Balsara, J Jadhav
unpublished
Sodium valproate, a broad spectrum antiepileptic drug elevates the brain gamma amino butyric acid (GABA) levels by various mechanisms. Valproate at 200-500mg/kg induces wet dog shake (WDS) behavior in rats. The WDS behavior in rats and head twitch responses (HTR) in mice is evoked by 5-hydroxytryptamine (5-HT, serotonin), the 5-HT precursor, the directly acting non-selective 5-HT receptor agonists and 5-HT releasers. In order to determine the GABAergic and 5-HTergic involvement in the induction
more » ... nt in the induction of WDS behavior in rats the study was taken up to investigate the effect of clomipramine pretreatment on sodium valproate, dexfenfluramine and 5-hydroxytryptamine (5-HTP) induced WDS behavior in rats.
fatcat:vdg4muzyxbgqnivbkq6qxk54au