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affected with the most distressing itching, without any outward manifestation whatever; and the paroxysms, which ten days before had been chiefly at night, were now less intermittent, and present throughout the day. The incessant irritation and loss of sleep threatened to undo all the good effects of the change; the more so, that the pernicious mental reaction produced by the patient brooding over her misery, and dreading its results, probably aggravated the intensity of the prulitus indoi:10.1136/bmj.2.612.324 fatcat:sysujexibzeqlp4b6xjpojbio4