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Autoimmune Encephalitis as an Extra-articular Manifestation of Rheumatoid Arthritis

Eiji Kitamura, Yuko Kondo, Naomi Kanazawa, Tsugio Akutsu, Kazutoshi Nishiyama, Takahiro Iizuka
2019 Internal medicine (Tokyo. 1992)  
Autoimmune encephalitis (AE) is an immune-mediated encephalitis characterized by the subacute onset of memory deficits, altered mental status, or psychiatric symptoms. Limbic encephalitis associated with rheumatoid arthritis (RA) has not been reported yet. A 57-year-old man presented with the subacute onset of headache, depression, and anorexia 7 months before the onset of RA. Brain magnetic resonance imaging showed symmetric parenchymal lesions involving the medial temporal lobes. He was
more » ... lobes. He was diagnosed with RA and AE, but no autoantibodies to neuronal intracellular or cell-surface antigens were identified in either the serum or cerebrospinal fluid. His symptoms improved with immunotherapy. AE can develop as an extra-articular manifestation of RA.
doi:10.2169/internalmedicine.1846-18 fatcat:bdc2rin7wfei5nmzkms2lfxwla