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Preliminary Evaluation of Hepatorenal Protective Potentials of Kigelia africana Ethanolic Leaf Extract on Carbon Tetrachloride Induced Toxicity in Adult Male Wistar Rats

Wandiahyel Yaduma Gaiuson, Nachamada Emmanuel Solomon, Neftiya Yaduma, Ibrahim Malgwi Samaila, Dluya Thagriki
2020 American Journal of Plant Sciences  
and aim: Hepatorenal toxicity is a very common ailment with resultant deleterious burden on the overall body systems and high mortality rate. Although myriads of drug agents are in circulation, its medical management is still inadequate as no effective treatment which inhibits disease progression and complications, has been synthesized yet. Therefore, this study focused on the potentials of Kigelia africana ethanolic leaf extract (KAELE) in preventing hepatorenal toxicity using CCl 4 model of
more » ... ng CCl 4 model of toxicity in rats. Method: KAELE was subjected to phytochemical screening. Following two-week acclimatization, thirty-six (N = 36) adult male Wistar rats were grouped into six consisting of six animals each (n = 6). Group I was given distilled water as control while groups II to VI received silymarin (100 mg/kg), CCl 4 (1 ml/kg), KAELE (100 mg/kg, 200 mg/kg and 400 mg/kg) respectively. All groups pre-treated with silymarin and Kigelia africana ethanol leaf extract lasted for a period of fourteen (14) days using a gastric tube. CCl 4 was administered intraperitoneally to groups II, III, IV, V and VI 48 hours after the last pretreatment on day 14. Post treatment, animals were sacrificed and the blood obtained and sera used for biochemical analysis while the tissues for histological evaluations. Results: The phytochemical tests revealed the presence of flavonoids,
doi:10.4236/ajps.2020.119096 fatcat:vahe4tcypfbnpdle23ybhhcyhy