Filters








1 Hit in 0.047 sec

O-015CLINICAL MANAGEMENT OF ATYPICAL CARCINOID AND LARGE CELL NEUROENDOCRINE CARCINOMA: A MULTICENTRE STUDY ON BEHALF OF THE ESTS LUNG NEUROENDOCRINE TUMOUR WORKING GROUP

Pier Luigi Filosso, O. Rena, F. Guerrera, P. Moreno Casado, D. Sagan, F. Raveglia, A. Brunelli, S. Welter
2013 Interactive Cardiovascular and Thoracic Surgery  
Objectives: In 2012 ESTS created the Lung Neuroendocrine Tumours Working-Group (NETs-WG) with the aim to develop scientific knowledge concerning clinical management of such rare neoplasms. This paper wants to outline outcome and prognostic factors of two aggressive NETs: atypical carcinoids (ACs) and large-cell neuroendocrine carcinomas (LCNCs). Methods: Using the ESTS-NETs-WG database, we retrospectively collected 216 patients in 7 Institutions in Europe, between 1994 and 2011. We used the
more » ... 11. We used the Coxregression model to evaluate variables affecting patients survival and competing-risk regression models (competing event: death by any causes) to estimate those which augment the risk of developing recurrences. Results: We found that amongst ACs, age (P < 0.001), paraneoplastic syndromes (P = 0.002), pT4 (P = 0.03) and N2 lymph-nodal involvement (P = 0.01) were negative prognostic factors (PFs); amid LCNCs, only pT4 tumours (P = 0.02) negatively affected the outcome. Recurrences developed in 80 patients and were statistically more frequent in LCNC (HR: 2.27; 95% CI: 1.28-4.06). Conclusions: With this study we confirmed the AC and LCNC biological aggressiveness. We hope that these results will be soon confirmed with the improvement of the ESTS Lung NETs-database. Disclosure: All authors have declared no conflicts of interest. Interactive CardioVascular and Thoracic Surgery
doi:10.1093/icvts/ivt288.15 fatcat:twmls7l3x5fndct4i4f7k3gocy