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External anions relieve DIDS inhibition of SO4 efflux from placental membrane vesicles

D. B. Shennan, C. A. R. Boyd
1986 Bioscience Reports  
Abbreviations: DIDS, 4-acetamido-4'-isothiocyanostilbene-2-2'-disulphonate Sulphate efflux from human placental microvillus membrane vesicles was inhibited by external DIDS (KI---10 .6 M). This inhibition was partially reversed on addition of the translocated substrates sulphate or selenate to the external medium: selenite which is not translocated does not protect against DIDS inhibition. These findings show that the mechanism responsible for sulphate efflux can be modified by substrate in the
more » ... by substrate in the external medium.
doi:10.1007/bf01116242 pmid:3828490 fatcat:j6luqe4vjfhczed4onsefgascq