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The hydroalcoholic extract of the steam bark of B. fagaroides var. fagaroides displayed potent cytotoxic activity against four cancer cell lines, namely KB (ED 50 = 9.6 × 10 −2 μg/mL), PC-3 (ED 50 = 2.5 × 10 −1 μg/mL), MCF-7 (ED 50 = 6.6 μg/mL), and HF-6 (ED 50 = 7.1 × 10 −3 μg/mL). This extract also showed anti-tumour activity when assayed on mice inoculated with L5178Y lymphoma cells. Bioactivity-directed isolation of this extract, afforded seven podophyllotoxin-type lignans identified asdoi:10.3390/molecules17089506 pmid:22878225 fatcat:qzengmlk2bg37exo6eo4dlcdmy