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The phenomenon of skin aging may be categorized broadly into photoaging caused by exogenous factors and physiological aging induced by endogenous factors. A near-infrared diffuse reflectance (NIR-DR) spectroscopy method was recently proposed for non-invasive evaluation of changes that occur within the skin of hairless mice that were divided into an ultraviolet-B (UVB)-irradiated group (photoaging) and a non-irradiated group (physiological aging). In the present study, a non-invasive method todoi:10.2116/analsci.28.1159 pmid:23232235 fatcat:mdjuk7n3ejch5nwjcktngs4rnu