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Comparative Evaluation of Intravenous vs. Nebulized Colistin Treatment of Pneumonia Due to Multidrug-Resistant Acinetobacter baumannii & Pseudomonas aeruginosa

안서현, 안혜림, 황보신이, 이수진
2020 Journal of Korean Society of Health-System Pharmacists  
: Multidrug resistant (MDR) Acinetobacter baumannii (A. baumannii) and Pseudomonas aeruginosa (P. aeruginosa) have emerged as major pathogens of pneumonia in the intensive care unit (ICU). Colistin is used as a drug of choice against pneumonia caused by these pathogens, but when it is administrated systemically, adverse effects such as renal toxicity and neurotoxicity limit its application. Recently, nebulized treatment of colistin has been widely applied to reduce these adverse effects, but
more » ... rse effects, but the clinical data of nebulized colistin has been limited. The purpose of this study was to compare the efficacy and safety of nebulized colistin with intravenous colistin. Methods : A retrospective medical records review was conducted on patients admitted to the ICUs at a teaching hospital. The patients were diagnosed with pneumonia caused by MDR A. baumanniior P. aeruginosa and treated with colistin either by intravascular or
doi:10.32429/jkshp.2020.37.1.001 fatcat:2gdaroi2bjdevhs46licx6vxw4