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The angiotensin converting enzyme (ace) gene polymorphism: Insight study of the renal regulation of the arterial blood pressure

Tijana Durmic, Zoran Mihailovic, Marija Zdravkovic, Oliver Stojkovic
2016 Medicinski Podmladak  
Since the renin-angiotensin-aldosterone system (RAAS) was originally described, it has become one of the best described hormonal systems, especially regarding the fact that it plays an important role in regulating blood volume and systemic vascular resistance, and thus indirectly influencing blood pressure (BP). On the other hand, arterial hypertension is one of the most pertinent disorders which plays an important role, not only in the progression of renal failure, but also represents a risk
more » ... represents a risk factor for the occurrence of end stage renal disease. Several epidemiological studies pointed out the fact that genetic predisposition accounts for about 30% of the BP variability. Up to date, there are several RAAS genes that may have effect in long-term BP control, but ACE is the most important and the most thoroughly examined. In this review, we present available data regarding the influence of gene polymorphisms of ACE on its function, within the RAAS related BP regulation. Therefore, by specially describing all its potential physiological roles, it will likely offer a new insight in the renal regulation of the BP, along with its other, not less important, roles. Keywords: blood pressure regulation, rennin-angiotensin-aldosterone system, ACE gene polymorphisms Durmić T. et al. The angiotensin converting enzyme (ACE) gene polymorphism -insight of the renal regulation of the arterial blood pressure, MedPodml 2016, 67(3):31-35 Medicinski podmladak / Medical Youth 32 SAŽETAK Od kako je sistem renin-angiotenzin-aldosteron (RAAS) opisan, postao je jedan od najčešće proučavanih fizioloških sistema, posebno imajući u vidu da ima veoma značajnu ulogu u regulaciji volumena krvi i sistemskog vaskularnog otpora, te na indirektan način utiče i na arterijski krvni pritisak (KP). S druge strane, arterijska hipertenzija predstavlja jednu od najznačajnijih bolesti današnjice, koja igra značajnu ulogu ne samo u progresiji bubrežne slabosti, već takođe predstavlja i faktor rizika za nastanak terminalne bubrežne insuficijencije. Nekoliko epidemioloških studija ukazuje na činjenicu da 30% varijabilnosti KP nastaje usled genetske predispozicije. Do danas, je otkriveno nekoliko RAAS gena koji mogu da imaju uticaj na dugoročnu kontrolu KP, ali je inserciono/delecioni (I/D) polimorfizam gena za angiotenzin konvertujući enzim (ACE) najznačajniji i najviše proučavan. U ovom pregledu literature predstavićemo dostupne podatke iz literature o uticaju I/D polimorfizma ACE gena na funkciju RAAS regulacije KP. Pomoću posebnog osvrta na sve njegove potencijalne fiziološke uloge, predstavićemo i novi pogled u bubrežnu regulaciju KP, kao i u njegove ostale, ne manje značajne uloge. Ključne reči: regulacija krvnog pritiska, sistem renin-angiotenzinaldosteron, polimorfizmi gena za angiotenzin konvertujući enzim
doi:10.5937/mp67-12811 fatcat:6taf4bs5q5gkvk7rmi6xok5k2i