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The aim of this study was to determine the efficacy of combination therapy based on acceptance, commitment and hope in improving quality of life in patients with cancer in Yasuj. The research method is a semi-experimental design with pre-test and post-test design with two experimental and control groups. The statistical population of this study included 100 cancer patients who were admitted to Yasuj Shahid Beheshti Hospitals in the 3rd month of 1396 and the first two months of 2018and havedoi:10.22054/QCCPC.2019.38404.2043 doaj:ddac3ef9c99143e0b5e6fe2444ab0500 fatcat:f5zpo5fr3bg73jbu47wfdvgogm