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Ninjurin 2 rs118050317 gene polymorphism and endometrial cancer risk [post]

Yimin Cheng, Liting Yang, Guangyao Shi, Peng Chen, Liang Li, Hangrong Fang, Chao Chen
2020 unpublished
Background: Endometrial cancer is one of the most common female reproductive system tumors. Ninjurin2 (NINJ2) is a new adhesion factor. As a vascular susceptibility gene, it is highly expressed in other cancers and promotes the growth of cancer cells. We conducted an association analysis between NINJ2 gene polymorphism and endometrial cancer risk.Methods: Five SNPs rs118050317, rs75750647, rs7307242, rs10849390 and rs11610368 of NINJ2 gene were genotyped in 351 endometrial cancer patients and
more » ... ncer patients and 344 healthy controls. The clinical index difference between cases and controls were tested by one-way analysis of variance. The allele and genotype frequency of cases and controls were been compared by Chi-square test. The odds ratios (OR) with 95% confidence interval (95% CI) were examined by logistic regression analysis. Results: The SNP rs118050317 mutant allele C and homozygote CC genotype were significant increased the endometrial cancer risk (OR = 1.46, 95% CI = 1.04 – 2.06, p = 0.028; OR = 8.43, 95% CI = 1.05 – 67.89, p = 0.045). In the clinical index analysis, there were significant higher quantities of CEA, CA125 and AFP in cases serum than controls.Conclusion: The NINJ2 gene polymorphism loci rs118050317 mutant allele C was associated with an increased risk of endometrial cancer. CEA, CA125 and AFP quantities were significant higher in endometrial cancer patients.
doi:10.21203/rs.3.rs-35102/v2 fatcat:m5ekh4aqyfhb7fgqriwu7ucli4