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Salvia miltiorrhiza Bunge extract was investigated for the first time for its inhibitory activity against pancreatic lipase (PL), an important enzyme involved in the digestion of dietary fats. It showed a concentration-dependent activity with an IC50 value of 3.54 ± 0.22 mg/mL. Two compounds, cryptotanshinone and tanshinone IIA (the major lipophilic constituents of S. miltiorrhiza), have been selected as potential ligands of PL. Cryptotanshinone showed a higher lipase inhibitory activity (IC50doi:10.6084/m9.figshare.8152613 fatcat:76fjiqkqbbe2tihpief4vbtxgq