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ROC Curve in Evaluation of Diagnostic Value of Serum 25-hydroxyvitamin-D for PCOS with Depression

2020 Journal of the College of Physicians and Surgeons  
The objective of this study was to apply receiver operating characteristic (ROC) curve to evaluate diagnostic value of serum 25-hydroxyvitamin-D [25-(OH)D] for polycystic ovarian syndrome (PCOS) combined with depression. Serum 25-(OH)D level was determined in 106 PCOS patients. Beck depression scale (BDI) and ROC curve were used to assess the objective. Results showed that there were 40 cases (37.74%) in combined depression group, and 66 (62.26%) in non-combined depression group. Number of
more » ... oup. Number of patients with depression family history and BDI score in combined depression group were higher than those in non-combined depression group (p=0.002 and p<0.001, respectively). Serum 25-(OH)D level in combined depression group was lower than that in non-combined depression group (p<0.001). Area under ROC curve for prediction of PCOS combined with depression by serum 25-(OH)D was 0.829 (95% CI=0.746-0.911). Clinical point value of diagnosis of serum 25-(OH)D was 10.89 μg/L. Sensitivity was 75% and specificity was 78.8%. Key Words: Serum, 25-hydroxyvitamin-D [25-(OH)D], Polycystic ovarian syndrome (PCOS) , Depression, Receiver operating characteristic (ROC) curve.
doi:10.29271/jcpsp.2020.06.659 pmid:32703357 fatcat:w4w2eylf6ffmrbdxybaovt6exm