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Objectives : To investigate potential interactions between bone morphogenetic protein (BMP) and Wnt signalling on differentiating mouse embryonic stem cells (mESC). Materials and methods : Mouse embryonic stem cells were cultured with differing combinations of Wnt3a, BMP4 and inhibitors of Wnt, BMP, PI-3K (phosphoinositide 3-kinase), p38, ERK1/2 (extracellular signal-regulated kinase 1/2) and JNK (c-Jun N-terminal kinase) pathways. Results : We found that Wnt3a synergized with BMP4 to promotedoi:10.1111/j.1365-2184.2008.00535.x pmid:18422702 fatcat:ukqbmtl35zaqpel7vfwq2e2quy