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LRH1 promotes tumor cell proliferation, migration and correlates with poor prognosis in ovarian cancer [post]

Wenzhou Sun, Qingtao Shi, Jiaxin Li, Jinmeng Li, Libo Yu
2020 unpublished
Background Recent studies have revealed that liver receptor homolog 1 (LRH1) plays a vital role in several human cancers, but its role in ovarian cancer (OC) remains unclear. We aimed to investigate whether LRH1 protein can act as a promising biomarker to predict the prognosis and metastasis in OC patients.Methods LRH1 expression status was evaluated by immunohistochemical and reverse transcription (RT)-qPCR analysis. The effects of LRH1 on tumor cell proliferation and progression were
more » ... ssion were evaluated in vitro. Results RT-qPCR showed that LRH1 mRNA expression was more intense in the invasive lesions (P < 0.05). LRH1 overexpression were extremely related with elevated FIGO stage (P = 0.001), lymph node metastasis (P = 0.011), and peritoneal metastasis (P = 0.001). Furthermore, LRH1 expression was an independently prognostic index for disease-free survival in OC patients (P = 0.041). In addition, LRH1 overexpression (P=0.011) along with FIGO stage (P<0.001) and ascites (P=0.015) independently affect peritoneal metastasis in OC patients. LRH1 knockdown significantly inhibited the proliferation, migration, and metastasis of human OC cells (P < 0.05).Conclusions The present study provides evidence that LRH1 predicts peritoneal metastasis and poor outcome, highlighting its potential role as biomarker for targeted therapy in OC.
doi:10.21203/ fatcat:4u2lwfmlxzbdtnnsdyox6zawxe