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Effects of Beer Administration in Mice on Acute Toxicities Induced by X Rays and Carbon Ions

MANAMI MONOBE, SACHIKO KOIKE, AKIKO UZAWA, KOICHI ANDO
2003 Journal of Radiation Research  
Beer/Radioprotection/LD 50/30 /Crypt survival/Chromosome aberration. We have investigated the tissue specificity of radioprotection by beer, which was previously found for human lymphocytes. C3H/He female mice, aged 14 weeks, received an oral administration of beer, ethanol or saline at a dose of 1 ml/mouse 30 min before whole-body irradiation with 137 Cs γ rays or 50 keV/µm carbon ions. The dicentrics of chromosome aberrations in spleen cells were significantly (p < 0.05) reduced by beer and
more » ... duced by beer and ethanol-administration for γ-ray irradiation, but not for carbon-ion irradiation. The number of jejunal crypts plotted against the dose showed that both beer and ethanol significantly increased D 0 (slope of a dosesurvival curve) for γ rays and carbon ions as well. Beer administration significantly (p < 0.05) increased LD 50/ 30 (radiation dose required to kill 50% of mice within 30 days) for γ rays and carbon ions. Ethanol-administration also significantly (p < 0.05) increased the LD 50/30 value for γ rays, but not for carbon ions. It is concluded that beer administration reduces the radiation injury caused by photons and carbon ions, depending on the tissue type. Radioprotection by beer administration is not solely due to OH radical-scavenging action by the ethanol contained in beer. Plasma ethanol concentration The plasma ethanol concentration was determined using a
doi:10.1269/jrr.44.75 pmid:12841603 fatcat:z5tvo2ioyre2plmcie2lntppzu