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VIIth International Congress on Thrombosis and Haemostasis
The ability of heparin fractions of different MW (mean MW 8500-30,000) to potentiate the action ot antithrombin III against the coagulation factors thrombin and Xa has been examined in purified reaction mixtures and in plasma. Residual thrombin and Xa have been determined by their peptidase activities against the synthetic peptide substrates H-D-Phe Pip-Arg-pNA and Bz-Ile-Glu-Gly-Arg-pNA. High MW heparin fractions were found to have higher anticoagulant activities than low MW heparin whendoi:10.1055/s-0039-1684675 fatcat:2p4rrv4rjfgytdcy2gurmbp7gu