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Multidrug-Resistant Tuberculosis: Review of the Literature from A Case of Choroidal Granuloma Associated with a Pott's Disease Secondary to a Pulmonary Localization

Atipo-Tsiba PW
2017 JOJ Ophthalmology  
Multidrug-resistant tuberculosis (MDR-TB) is due to resistance of Koch's Bacillus to Rifampicin and / or Isoniazid. Another therapeutic protocol called second line is necessary. It combines in attack phase (6 months) an aminoside, a fluoro quinolone, Ethionamide and Pyrazinamide. The maintenance phase (12 to 18 months) is constituted by a fluoroquinolone, Ethionamide, and Pyrazinamide. Ethambutol may be associated with both phases if the genetic analyzes prove that it is active on the causal
more » ... ve on the causal strain. New molecules (Bedaquiline, Delamanide) are already in use in so-called ultra-resistant forms when the second classical line is ineffective. All these drugs are not part of the national tuberculosis programs. Their cost is a real brake in Africa. The aim of this work was to examin literature review on MDR-TB from a case with pulmonary, bone and ocular involvement.
doi:10.19080/jojo.2017.04.555636 fatcat:ptefzycoqzg2vnrosb55inbxjy