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Necrotizing enterocolitis (NEC) is the most common serious, acquired gastrointestinal disorder in the newborn infant. Although many variables are associated with development of NEC, only prematurity has been consistently identified in case-controlled studies. Traditionally, the diving seal reflex has been invoked as the mechanism responsible for ischaemic injury and necrosis. Intestinal ischaemia is likely to be the final common pathway in NEC; however, it is due to the release ofdoi:10.1016/s1084-2756(03)00123-4 pmid:15001117 pmcid:PMC7128229 fatcat:vphiaczbxraprjb7cjegdi3xtq