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Osteopontin as a predictive factor of requirement to primary surgical intervention and a prognostic factor in small intestinal non-Hodgkin lymphoma

Zheng-Yi Huang, Yu-Guang Chen, W Tsai, Yi-Ying Wu, Tzu-Chuan Huang, Jia-Hong Chen
2016 Academia Journal of Biotechnology   unpublished
The treatments for intestinal non-Hodgkin lymphoma (NHL) have not been established. Primary surgical resection seemed a rational choice because it can establish the diagnosis and reduce the tumor burden. The authors found that NHL with jejunum involvement may more require for primary surgical intervention following chemotherapy. However, the surgical rate of jejunum involvement was 9.3 to 23.8%. Osteopontin (OPN) plays a role in tumorigenesis, invasion, and metastasis of human cancers. This
more » ... n cancers. This study is aimed to explore the influence of OPN in small intestinal NHL. A retrospective analysis between 1995 and 2010 was collected from clinical data. Fourteen cases of primary small intestinal NHL were identified. Anti-OPN mouse monoclonal antibody was applied to these lymphoma tissues. Seven patients (50%) experienced abdominal pain and/or distention. Jejunum involvement was presented in 8 of 14 patients (57.1%). Surgical treatment was performed in 5 of 8 patients with jejunum involvement. We found those with OPN expression ≥ 50 had significant higher operation risk (OR = 18, p = 0.044). Linear regression confirmed that there was a significant association of score of OPN in intestinal NHL and survival time (P = 0.034, r =-0.641, respectively), indicating a correlation of the increased OPN score and decreased survival time. In conclusion, the results explain that OPN and the involved site may be as predictive factors of requirement to primary surgical intervention. We found a trend that OPN can be considered as a prognostic factor in small intestinal NHL, although the subgroups were too small for individual analysis.