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An Efficient and Simple Route to Prospective Biologically Active Isoindoloquinazoline, Pyrimidine and Thiazine Derivatives Using 2-Amino-N'-Arylbenzamidine and Related Compounds as Starting Materials

F. F. Abdel-Latif, K. M. El-Shaieb, A. G. El-Deen
2011 Zeitschrift für Naturforschung. B, A journal of chemical sciences  
The reaction of (Z)-2-amino-N -arylbenzamidines 1, 2-amino-4,5,6,7-tetrahydrobenzo[b]-thiophene-3-carboxamide (4) and 4-amino-5-substituted-2-(phenylamino)thiophene-3-carboxamides 12 with o-phthalaldehyde (2), terephthalaldehyde (9), and 4-formyl[2.2]paracyclophane (16) in ethanol under reflux conditions afforded isoindoloquinazoline, thienopyrimidine, pyrimidine and thiazine derivatives, respectively. The products were characterized based on their spectroscopic data and elemental analysis.
doi:10.5560/znb.2011.66b0965 fatcat:h2nfxecszzatzcvwdejh564plq