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Aquaporin-4 Autoantibodies in a Paraneoplastic Context

Sean J. Pittock, Vanda A. Lennon
2008 Archives of Neurology  
The neuromyelitis optica IgG autoantibody (NMO-IgG) is a validated biomarker for NMO and an emerging spectrum of inflammatory central nervous system-demyelinating disorders. Its antigen is the astrocytic water channel aquaporin-4; NMO-IgG has not been described in a cancer context. Objectives: To report (1) neurologic and oncologic correlates for patients incidentally identified as NMO-IgG seropositive in a blinded evaluation for paraneoplastic autoantibodies and (2) the frequency of cancer in
more » ... uency of cancer in NMO-IgG-seropositive patients. Design: Observational, retrospective case series.
doi:10.1001/archneur.65.5.629 pmid:18474738 fatcat:pabo2ebouncefpicm57fuz4yma