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SA89. Altered Brain Gyrification in Deficit and Nondeficit Schizophrenia

Yoichiro Takayanagi, Daiki Sasabayashi
2017 Schizophrenia Bulletin  
Posters (Saturday) S145 differences in hippocampal subfield volumes. All tests were corrected for age, sex, body mass index, and total intracranial volume, and test within the FEP group were also corrected for antipsychotic medication. After excluding subjects with diabetes, we tested associations between fasting glucose (<6.2 mmol/l), insulin, HOMA-index, clinical symptoms, and the subfield volumes. Results: We found that several hippocampal subfields (ROI) were significantly smaller in FEP
more » ... y smaller in FEP than in controls (ROI × Group P = .010, Partial η 2 .039). In FEP patients particularly molecular layer (P = .001, left β = −38.95, right β = −27.81), subiculum (P = .028, left β = −19.71, right β = −13.35), CA1 (P = .016, left β = −29.73, right β = −28.58) and presubiculum (P = .004, left β = −14.01, right β = −13.92) were smaller than in the controls. Blood fasting glucose-dependent group interaction was found between FEP and control group (Group × Glucose P = .038). Glucose correlated positively with hippocampal volumes in the controls but not in the FEP. In FEP group, fasting glucose levels correlated negatively with volumes in right subiculum (P = .033, β = −25.13), left presubiculum (P = .004, β = −29.31) and right presubiculum (P = .038, β = −21.04). Cognitive tests or symptom severity were not associated with the hippocampal subfield volumes. Conclusion: We showed that hippocampal subregions are differently affected already in the first episode of psychosis. We found that several hippocampal subfields were differently associated with blood glucose levels in FEP and control group. The findings do not provide evidence for causal relationships but suggest that hippocampal subregions are differently involved in the regulation of glucose metabolism in FEP and control group. The results suggest FEP patients are susceptible to the negative effects of impaired glucose metabolism. Background: The white matter (WM) connections between the substantia nigra and the striatum are part of a complex neural system involved in rewardbased learning, a process that is impaired in patients with schizophrenia. Most
doi:10.1093/schbul/sbx023.087 fatcat:7rrbisvknnfhrfyoxj7nwzicmq