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Phosphoinositide 3-Kinase (PI3K) ␥ is a lipid kinase that is regulated by G-protein-coupled receptors. It plays a crucial role in inflammatory and allergic processes. Activation of PI3K␥ is primarily mediated by G␤␥ subunits. The regulatory p101 subunit of PI3K␥ binds to G␤␥ and, thereby, recruits the catalytic p110␥ subunit to the plasma membrane. Despite its crucial role in the activation of PI3K␥, the structural organization of p101 is still largely elusive. Employing fluorescence resonancedoi:10.1074/jbc.m413104200 pmid:15611065 fatcat:scni2qthrff3zlgyvubmm4tvge