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Testing of Semichronically Implanted Retinal Prosthesis by Suprachoroidal-Transretinal Stimulation in Patients with Retinitis Pigmentosa

Takashi Fujikado, Motohiro Kamei, Hirokazu Sakaguchi, Hiroyuki Kanda, Takeshi Morimoto, Yasushi Ikuno, Kentaro Nishida, Haruhiko Kishima, Tomoyuki Maruo, Kunihiko Konoma, Motoki Ozawa, Kohji Nishida
2011 Investigative Ophthalmology and Visual Science  
PURPOSE. To examine the safety and effectiveness of a retinal prosthesis that is implanted semichronically in two patients with advanced retinitis pigmentosa (RP). METHODS. Two eyes of two patients with advanced RP had a retinal prosthesis implanted in a sclera pocket of one eye. The visual acuity of both eyes before the implantation was bare light perception. Phosphenes were elicited by suprachoroidaltransretinal stimulation (STS). The internal devices of the STS were implanted under the skin
more » ... ted under the skin on the temporal side of the head, and the 49 electrode-array was implanted in the scleral pocket of one eye. Biphasic electrical pulses (duration, 0.5 ms; frequency, 20 Hz) were delivered through nine active electrodes. The threshold current was determined by currents Յ1 mA. Behavioral tasks were used to determine the functioning of the prosthesis. RESULTS. The surgery was completed without a retinal detachment and retinal/vitreous hemorrhage. The implanted STS system remained functional for the 4-week test period. Phosphenes were elicited by currents delivered through six electrodes in Patient 1 and through four electrodes in Patient 2. The success of discriminating two bars was better than the chance level in both patients. In Patient 2, the success of a grasping task was better than the chance level, and the success rate of identifying a white bar on a touch panel increased with repeated testing. CONCLUSIONS. Semichronic implantation of a microelectrode-STS system showed that it was safe and remained functional for at least 4 weeks in two patients with advanced RP. (www.umin. number, R000002690.) (Invest Ophthalmol Vis Sci.
doi:10.1167/iovs.10-6836 pmid:21436271 fatcat:5ux2447msrbnrgg72xfi3w6bze