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Int J Clin Exp Pathol
Radiation-induced lung injury (RILI) is a common complication after thoracic radiotherapy and epithelial-to-mesenchymal transition (EMT) an important change among this process. The aim of this study was to determine the role of miR-21 in radiation-induced EMT in alveolar epithelial type II cells RLE-6TN and explored the underlying molecular mechanism. The results showed that treating RLE-6TN cells with 8 Gy of X-ray promoted EMT and resulted in up-regulation of miR-21. Transfection of Rle-6TNfatcat:ploxtct73ndt7oa2ec2x3jc7l4