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Structure-based antivirals for emerging and neglected RNA viruses: an emerging field for medicinal chemistry in academia

Rolf Hilgenfeld
2010 Future Medicinal Chemistry  
Recently, two articles addressed the question of how the protease can liberate itself from the viral polyprotein, of which it is an integrated part (nonstructural protein 5) before auto-cleavage.  ...  HIVdb: a database of the structures of human immunodeficiency virus protease. Proteins 49, 429-431 (2002). 11 Lee CC, Kuo CJ, Ko TP, et al.  ... 
doi:10.4155/fmc.10.211 pmid:21426155 fatcat:jlasuix72vahrpn33hpgicllie

Human immunodeficiency virus integrase inhibitors efficiently suppress feline immunodeficiency virus replication in vitro and provide a rationale to redesign antiretroviral treatment for feline AIDS

Andrea Savarino, Mauro Pistello, Daniela D'Ostilio, Elisa Zabogli, Fabiana Taglia, Fabiola Mancini, Stefania Ferro, Donatella Matteucci, Laura De Luca, Maria Barreca, Alessandra Ciervo, Alba Chimirri (+2 others)
2007 Retrovirology  
Of note, the naphthyridine carboxamide INSTI, L-870,810 displayed an EC 50 in the low nanomolar range. Inhibition of FIV integration in situ was shown by real-time PCR  ...  The interaction of the transferred strand of viral DNA with the catalytic cavity of FIV IN was deduced from a crystal structure of a structurally similar transposase complexed with transposable DNA.  ...  Special thanks are given to Merck and Co. for free providing of L-870,810.  ... 
doi:10.1186/1742-4690-4-79 pmid:17971219 pmcid:PMC2244644 fatcat:opyv5r4qzraxzaopx4hteqbkni