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Recently, two articles addressed the question of how the protease can liberate itself from the viral polyprotein, of which it is an integrated part (nonstructural protein 5) before auto-cleavage. ... HIVdb: a database of the structures of human immunodeficiency virus protease. Proteins 49, 429-431 (2002). 11 Lee CC, Kuo CJ, Ko TP, et al. ...doi:10.4155/fmc.10.211 pmid:21426155 fatcat:jlasuix72vahrpn33hpgicllie
Of note, the naphthyridine carboxamide INSTI, L-870,810 displayed an EC 50 in the low nanomolar range. Inhibition of FIV integration in situ was shown by real-time PCR ... The interaction of the transferred strand of viral DNA with the catalytic cavity of FIV IN was deduced from a crystal structure of a structurally similar transposase complexed with transposable DNA. ... Special thanks are given to Merck and Co. for free providing of L-870,810. ...doi:10.1186/1742-4690-4-79 pmid:17971219 pmcid:PMC2244644 fatcat:opyv5r4qzraxzaopx4hteqbkni