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gcMECM: graph clustering of mutual exclusivity of cancer mutations

Ying Hu, Chunhua Yan, Qingrong Chen, Daoud Meerzaman
2021 BMC Bioinformatics  
Results Here we describe a tool, gcMECM, that enables us to visualize the functionality of mutually exclusive genes in the subnetworks derived from mutation associations, gene–gene interactions, and graph  ...  Sequence analysis has revealed that cancer driver genes operate across multiple intricate pathways and networks with mutations often occurring in a mutually exclusive pattern.  ...  The Graph Clustering of Mutual Exclusivity of Cancer Mutations (gcMECM) is able to detect modules of different sizes with varying cutoffs and significance.  ... 
doi:10.1186/s12859-021-04505-w pmid:34906079 fatcat:vxz6ihp445d5faphoros5etsta