133 Hits in 7.1 sec

Whole brain dynamics during optogenetic self-stimulation of the medial prefrontal cortex in mice

Christopher G. Cover, Andrew J. Kesner, Shehzad Ukani, Elliot A. Stein, Satoshi Ikemoto, Yihong Yang, Hanbing Lu
2021 Communications Biology  
AbstractIntracranial self-stimulation, in which an animal performs an operant response to receive regional brain electrical stimulation, is a widely used procedure to study motivated behavior.  ...  Herein we report a method that permits functional MRI (fMRI) of brain dynamics while mice are cued to perform an operant task: licking a spout to receive optogenetic stimulation to the medial prefrontal  ...  Thomas Ross at the NIH for discussions on fMRI data processing and NIDA histological core facility for technical assistance.  ... 
doi:10.1038/s42003-020-01612-x pmid:33446857 fatcat:zy5zxe6bqnekjasrr2dh3xji6a

Optogenetic Activation of CA1 Pyramidal Neurons at the Dorsal and Ventral Hippocampus Evokes Distinct Brain-Wide Responses Revealed by Mouse fMRI

Norio Takata, Keitaro Yoshida, Yuji Komaki, Ming Xu, Yuki Sakai, Keigo Hikishima, Masaru Mimura, Hideyuki Okano, Kenji F. Tanaka, Adam J Schwarz
2015 PLoS ONE  
Brain-wide responses examined using fMRI revealed that optogenetic activation at the dHP or vHP caused blood oxygenation level-dependent (BOLD) fMRI signals in situ.  ...  In this study, we compared the spatial distribution of brain-wide responses upon dHP or vHP activation and further estimate connection strengths between the dHP and the vHP with corresponding extra-hippocampal  ...  Further, comparing reported BOLD signal changes of *0.5% in naïve rats upon continual 30-s blue-light illumination (2 mW) to 5*10% BOLD signal changes in our study, we conclude that heating artifacts are  ... 
doi:10.1371/journal.pone.0121417 pmid:25793741 pmcid:PMC4368201 fatcat:2cfo3zho2vb55azhlgez4lqpr4

Brain-wide mapping of neural activity mediating collicular-dependent behaviors [article]

Arnau Sans-Dublanc, Anna Chrzanowska, Katja Reinhard, Dani Lemmon, Gabriel Montaldo, Alan Urban, Karl Farrow
2020 biorxiv/medrxiv   pre-print
Here we reveal the brain-wide networks downstream of four collicular cell-types by combining functional ultrasound imaging (fUSi) with optogenetics to monitor neural activity at a resolution of ~100 μm  ...  Neuronal cell-types are arranged in brain-wide circuits to guide behavior. In mice, the superior colliculus is comprised of a set of cell-types that each innervate distinct downstream targets.  ...  In this study, we combined fUSi with optogenetics to reveal the whole-brain neuronal networks 457 that link individual cell-types of the SC with a triggered behavior.  ... 
doi:10.1101/2020.08.09.242875 fatcat:ozmgrrhdv5fbnggmw5ap4ttxw4

Predicting Successful Generation and Inhibition of Seizure-like Afterdischarges and Mapping Their Seizure Networks Using fMRI

Ben A. Duffy, ManKin Choy, Jin Hyung Lee
2020 Cell Reports  
To understand the conditions necessary to initiate and terminate seizures, we investigate optogenetically induced hippocampal seizures with LFP, fMRI, and optogenetic inhibition.  ...  These results provide insights into how seizures can be inhibited, which has implications for targeted seizure interventions.  ...  ACKNOWLEDGMENTS The authors thank all Lee lab members for their help with the experiments, discussions, and writing of the manuscript.  ... 
doi:10.1016/j.celrep.2020.01.095 pmid:32101734 pmcid:PMC8720841 fatcat:cnxqpayayjdqnlho3si2oh6rhi

Long-Term Memory Search across the Visual Brain

Milan Fedurco
2012 Neural Plasticity  
Here, I will review recent Blood Oxygenation Level-Dependent functional Magnetic Resonance Imaging (BOLD fMRI) in humans together with molecular biology studies (animal models) aiming to understand how  ...  Signal transmission from the human retina to visual cortex and connectivity of visual brain areas are relatively well understood.  ...  Acknowledgments The author would like to thank Professors. Sidney Whiteheart, Leslie G. Ungerleider, and Eva Pastalkova for helpful discussions. Dr.  ... 
doi:10.1155/2012/392695 pmid:22900206 pmcid:PMC3409559 fatcat:tugiiroglnbhnhrrnnstq73j4e

From Nose to Brain: Un-Sensed Electrical Currents Applied in the Nose Alter Activity in Deep Brain Structures

Tali Weiss, Sagit Shushan, Aharon Ravia, Avital Hahamy, Lavi Secundo, Aharon Weissbrod, Aya Ben-Yakov, Yael Holtzman, Smadar Cohen-Atsmoni, Yehudah Roth, Noam Sobel
2016 Cerebral Cortex  
Rules linking patterns of olfactory receptor neuron activation in the nose to activity patterns in the brain and ensuing odor perception remain poorly understood.  ...  To validate contact with the olfactory path, we used functional magnetic resonance imaging to measure resting-state brain activity in 18 subjects before and after un-sensed stimulation.  ...  Conflict of Interest: The Weizmann Institute Office of Technology Licensing is preparing an application for patent on "brain stimulation through the nose".  ... 
doi:10.1093/cercor/bhw222 pmid:27591145 pmcid:PMC5066827 fatcat:55timipeing53ecfihjywp7wpy

Whole-brain circuit dissection in free-moving animals reveals cell-specific mesocorticolimbic networks

Michael Michaelides, Sarah Ann R. Anderson, Mala Ananth, Denis Smirnov, Panayotis K. Thanos, John F. Neumaier, Gene-Jack Wang, Nora D. Volkow, Yasmin L. Hurd
2013 Journal of Clinical Investigation  
The ability to map the functional connectivity of discrete cell types in the intact mammalian brain during behavior is crucial for advancing our understanding of brain function in normal and disease states  ...  be directly studied in relation to exogenous stimulation.  ...  Importantly, a recent study showed that light delivery in the absence of optogenetic stimulation induced strong local fMRI responses in the stimulated site (3) .  ... 
doi:10.1172/jci72117 pmid:24231358 pmcid:PMC3859392 fatcat:l6gub72dqjemnlxybncyobk3fy

Dissociation of impulsive traits by subthalamic metabotropic glutamate receptor 4

Lukasz Piszczek, Andreea Constantinescu, Dominic Kargl, Jelena Lazovic, Anton Pekcec, Janet R Nicholson, Wulf Haubensak
2022 eLife  
Here, by combining a Go/No-Go behavioral assay with resting state (rs) functional MRI in mice, we identified the subthalamic nucleus (STN), a known gate for motor control in the basal ganglia, as a major  ...  Behavioral strategies require gating of premature responses to optimize outcomes.  ...  By combining small animal fMRI with circuit neuroscience methods (Kargl et al., 2020; Wank et al., 2021), we were able to identify brain hotspots accounting for natural variance in trait impulsivity in  ... 
doi:10.7554/elife.62123 pmid:34982027 pmcid:PMC8803315 fatcat:elj7pohilrdafcg6ngqn3mlfj4

Medial Prefrontal Cortex Interacts with the Anteromedial Thalamus in Motivation and Dopaminergic Activity [article]

Chen Yang, Yuzheng Hu, Aleksandr D Talishinsky, Christian T Potter, Leslie A Ramsey, Andrew J Kesner, Reuben F Don, Sue Junn, Aaron Tan, Anne F Pierce, Celine Nicolas, Coleman B Calva (+6 others)
2020 bioRxiv   pre-print
The stimulation of AM neurons projecting to the mPFC also reinforced behavior and activated dopamine neurons, and mPFC and AM showed a positive-feedback loop organization.  ...  Reciprocal excitatory functional connectivity, as well as co-activation of the two regions, was found in human participants who watched reinforcing videos.  ...  Acknowledgments: The authors thanks NIDA Transgenic Breeding Facility for transgenic mice, NIDA Genetic Engineering and Viral Vector Core for viral vectors and NIDA Histology Core for cell counting.  ... 
doi:10.1101/2020.05.19.104026 fatcat:f4ij2fbtlbgxjg2wcmtrq5r3i4

Local and global dichotomic dysfunction in resting and evoked functional connectivity precedes tauopathy [article]

Francesca Mandino, Ling Yun Yeow, Renzhe Bi, Sejin Lee, Han Gyu Bae, Seung Hyun Baek, Chun Yao Lee, Hasan Mohammad, Chai Lean Teoh, Jasinda Lee, Mitchell Kim Peng Lai, Sangyong Jung (+4 others)
2020 bioRxiv   pre-print
To reveal the physiological basis underpinning these changes at the onset of the pathology, we leveraged fMRI in the 3xTgAD mouse model for AD.  ...  Optogenetic activation of the entorhinal cortex results, instead, in enhanced fMRI signal, thus denoting an increase in metabolic demand under load.  ...  N. et al. fMRI response to blue light delivery in the naïve brain: implications for combined optogenetic fMRI studies. Neuroimage 66, 634-641 (2013). 55. Rungta, R. L., Osmanski, B.  ... 
doi:10.1101/2020.04.03.022590 fatcat:t6lwetdlezerrg5ed7a6jkkc5e

Evaluation of BOLD effects in the rat cortex [article]

Nathalie Just
2021 bioRxiv   pre-print
Purpose: This study aimed to characterize Blood oxygen level-dependent (BOLD) effects in 1H- MR spectra obtained during optogenetic activation of the rat forelimb cortex for the correction and estimation  ...  Conclusion : The linewidth-matching procedure using a precise lb factor remains the most performant approach for the accurate quantification of small (0.3 micromol/g) metabolic changes in 1H-fMRS studies  ...  Kasparov S, Gourine AV, Lythgoe MF fMRI 23 response to blue light delivery in the naïve brain: implications for combined optogenetic fMRI studies.  ... 
doi:10.1101/2021.05.12.443862 fatcat:pktsxrmqkfhibmf72p6y5lg77i

Functional dissection of neural circuitry using a genetic reporter for fMRI [article]

Souparno Ghosh, Nan Li, Benjamin B Bartelle, Tianshu Xie, Jade I Daher, Urvashi D Singh, Katherine Xie, Nicholas DiNapoli, Nicholas B Evans, Kwanghun Chung, Alan P Jasanoff
2020 bioRxiv   pre-print
Using a viral vector that undergoes retrograde transport, we apply the probe to characterize a brain-wide network of monosynaptic inputs to the striatum activated in a deep brain stimulation paradigm in  ...  The complex connectivity of the mammalian brain underlies its function, but understanding how interconnected brain regions interact in neural processing remains a formidable challenge.  ...  . a, Unbiased visualization of HSV-mCherry-infected brain regions in an entire cleared rat brain hemisphere following viral delivery to rat CPu.  ... 
doi:10.1101/2020.12.27.424403 fatcat:ademg6cxzvenfjfbyvmfhbgu2i

Viral vector-based tools advance knowledge of basal ganglia anatomy and physiology

Rachel J. Sizemore, Sonja Seeger-Armbruster, Stephanie M. Hughes, Louise C. Parr-Brownlie
2016 Journal of Neurophysiology  
However, viral vector use in neuroscience research has increased because they enhance interpretation of the anatomy and physiology of brain circuits compared with conventional tract tracing or electrical  ...  Here we review the use of viral vectors to examine the structure and function of motor and limbic basal ganglia (BG) networks in normal and pathological states.  ...  For ChR2, blue light (ϳ470 nm) opens a cation channel allowing Na ϩ to enter the cell, thus depolarizing it (Nagel et al. 2003) .  ... 
doi:10.1152/jn.01131.2015 pmid:26888111 pmcid:PMC4869490 fatcat:kpjcv7jbsradzjwn3saymwcn3u

Existence of Initial Dip for BCI: An Illusion or Reality

Keum-Shik Hong, Amad Zafar
2018 Frontiers in Neurorobotics  
Initial Dip in fMRI The first fMRI study on the initial decrease in the BOLD response was presented in 1995, in which the brain maps of human subjects were found to display a negative change in the signal  ...  So far, no study has used the initial dip response of the HR/BOLD to provide immediate feedback to the participants. The initial dip can help to reduce the neurofeedback time in fMRI-BCI.  ...  The reviewer NN declared a past co-authorship with one of the authors K-SH to the handling Editor. Copyright © 2018 Hong and Zafar.  ... 
doi:10.3389/fnbot.2018.00069 pmid:30416440 pmcid:PMC6212489 fatcat:wt5n5sakrbeqlecquoyizlaf4i

Supramammillary neurons projecting to the septum regulate dopamine and motivation for environmental interaction in mice

Andrew J. Kesner, Rick Shin, Coleman B. Calva, Reuben F. Don, Sue Junn, Christian T. Potter, Leslie A. Ramsey, Ahmed F. Abou-Elnaga, Christopher G. Cover, Dong V. Wang, Hanbing Lu, Yihong Yang (+1 others)
2021 Nature Communications  
Using optogenetics, we found that the excitation of SuM glutamatergic (GLU) neurons was reinforcing in mice; this effect was relayed by their projections to septal GLU neurons.  ...  However, recent studies reported that the stimulation of SuM neurons with neuroactive chemicals, including substances of abuse, is reinforcing.  ...  We thank the NIDA-IRP Optogenetics and Transgenic Technology Core and the Stanford Optogenetic Innovations lab for providing viral vectors and vector plasmids, respectively.  ... 
doi:10.1038/s41467-021-23040-z pmid:33990558 fatcat:3ozmwdiygna3jiwhihget763he
« Previous Showing results 1 — 15 out of 133 results