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fMRI mapping of the visual system in the mouse brain with interleaved snapshot GE-EPI

Arun Niranjan, Isabel N. Christie, Samuel G. Solomon, Jack A. Wells, Mark F. Lythgoe
2016 NeuroImage  
In addition, the use of interleaved snapshot GE-EPI improved fMRI image quality without diminishing the temporal contrast-noise-ratio.  ...  In this study, we map the mouse brain visual system with BOLD measurements at 9.4T using flashing light stimuli with medetomidine anaesthesia.  ...  Discussion This study aimed to investigate the use of GE-EPI with interleaved snapshots for mouse brain fMRI and characterise the BOLD functional response of the mouse brain to visual stimuli.  ... 
doi:10.1016/j.neuroimage.2016.06.015 pmid:27296012 pmcid:PMC4988789 fatcat:khlxrm5ixzhezobb4b3khnl4cu

Snapshot gradient-recalled echo-planar images of rat brains at long echo time at 9.4 T

Hongxia Lei, Vladimir Mlynárik, Nathalie Just, Rolf Gruetter
2008 Magnetic Resonance Imaging  
The aim of this study was to investigate the feasibility and quality of long TE snapshot GRE-EPI images of rat brain at 9.4 T.  ...  With improved B 0 homogeneity along with satisfactory gradient performance at high magnetic fields, snapshot gradient-recalled echoplanar imaging (GRE-EPI) would perform at long echo times (TEs) on the  ...  The work was supported by R01 NS042005 (NIH), the Centre d'Imagerie BioMédicale of the UNIL, UNIGE, HUG, CHUV and EPFL and the Leenaards and Jeantet Foundations.  ... 
doi:10.1016/j.mri.2008.01.009 pmid:18486393 pmcid:PMC2646166 fatcat:rypleuh43vbffhowavrqkxhxwa

Small animal neuroimaging using magnetic resonance microscopy

E.T Ahrens, P.T Narasimhan, T Nakada, R.E Jacobs
2002 Progress in nuclear magnetic resonance spectroscopy  
Fig. 3 shows a comparison of GE and SE images of an in vivo mouse brain acquired with comparable parameters.  ...  In fact, the ®rst fMRI maps of human brain function utilized CBV contrast [258] .  ... 
doi:10.1016/s0079-6565(02)00003-1 fatcat:twvecdhoyjbyvec4mfc5k4lt24

A novel anesthesia regime enables neurofunctional studies and imaging genetics across mouse strains

Marija M. Petrinovic, Georges Hankov, Aileen Schroeter, Andreas Bruns, Markus Rudin, Markus von Kienlin, Basil Künnecke, Thomas Mueggler
2016 Scientific Reports  
The novel anesthesia procedure based on the GABAergic anesthetic etomidate was extensively validated in fMRI studies conducted in a range of genetically engineered rodent models of autism and strains commonly  ...  The significantly improved preservation of cerebrovascular dynamics enhances sensitivity to neural activity changes for which it serves as a proxy in fMRI readouts.  ...  Analysis of BOLD fMRI data.  ... 
doi:10.1038/srep24523 pmid:27080031 pmcid:PMC4832200 fatcat:fgaxplriinhh7ekar2mkl34cqi

Genetically Determined Interaction between the Dopamine Transporter and the D2 Receptor on Prefronto-Striatal Activity and Volume in Humans

A. Bertolino, L. Fazio, A. Di Giorgio, G. Blasi, R. Romano, P. Taurisano, G. Caforio, L. Sinibaldi, G. Ursini, T. Popolizio, E. Tirotta, A. Papp (+3 others)
2009 Journal of Neuroscience  
The differential effect on BOLD activity of the DAT variant was mostly manifest in the context of the DRD 2 allele associated with lower presynaptic expression.  ...  Similar results were also evident for gray matter volume in caudate. These interactions describe a nonlinear relationship between compound genotypes and brain activity or gray matter volume.  ...  Preprocessing and statistical analyses of the fMRI data Analysis of the fMRI data was completed using statistical parametric mapping (SPM5;  ... 
doi:10.1523/jneurosci.4858-08.2009 pmid:19176830 pmcid:PMC2686116 fatcat:bbvmohq32zei7listuivs64ooy

5th International Symposium on Focused Ultrasound

Menashe Zaaroor, Alon Sinai, Dorit Goldsher, Ayelet Eran, Maria Nassar, Ilana Schlesinger, Jonathon Parker, Vinod Ravikumar, Pejman Ghanouni, Sherman Stein, Casey Halpern, Vibhor Krishna (+1008 others)
2016 Journal of Therapeutic Ultrasound  
BPN rapidly penetrate brain tissue due to a dense coat of polyethylene glycol, and this approach mediates efficient and localized transgene expression in the brain of healthy rats.  ...  Conclusions FUS-mediated delivery of systemically circulating non-viral GDNF-BPN to the striatum of 6-OHDA rats confers a significant behavioral benefit as well as a restoration of TH+ cell number in the  ...  Conclusions Resting state fMRI consistently shows that BOLD signal fluctuations are temporally correlated in brain regions that make up functional networks, such as the visual or sensorimotor systems.  ... 
doi:10.1186/s40349-016-0076-5 fatcat:4vm7i5mt6vheni3hflxd3pwl2i

ACNP 55th Annual Meeting: Poster Session III

2016 Neuropsychopharmacology  
evaluation of these two radioligands in a healthy rhesus monkey brain.  ...  Both 11C-PS13 and 11C-MC1 showed good uptake in monkey brain (peak concentrations of 3-5 SUV) and washed out relatively quickly (demonstrating that the binding was reversible, as expected).  ...  Then using interleaved fMRI/TMS, it was demonstrated that DTI-guided TMS could activate the deep target, and could do so in a dosage dependent manner.  ... 
doi:10.1038/npp.2016.242 fatcat:4efd43swjbboranfrcs3pp32h4

ACNP 58th Annual Meeting: Poster Session III

2019 Neuropsychopharmacology  
We plan on investigating the ability of JOTROL to prevent AD-like pathogenesis in AD mouse models.  ...  JOTROL resulted in 7-fold greater concentration in rat plasma than nonformulated resveratrol (p < 0.05), and a significant increase in resveratrol concentration in mouse brain.  ...  In parallel studies in rodents, we used transgenic mouse models specifically designed to selectively target and visualize the cholinergic system.  ... 
doi:10.1038/s41386-019-0547-9 pmid:31801974 pmcid:PMC6957926 fatcat:dd7d43ysfvc5bbbstfl73szya4

Poster Session II

2005 Neuropsychopharmacology  
Results: Results showed a significant increase in λ2 in the genu of the anterior corpus callosum in cocaine dependent subjects compared to controls.  ...  The purpose of this study was to compare cocaine dependent subjects with non-drug using controls using individual DTI eigenvalues.  ...  Schizophrenia is Associated with Increased Synaptic Dopamine in Associative Rather than Limbic Regions of the Striatum Marc Laruelle*, Lawrence S Kegeles, Gordon W Frankle, Raj Narendran, Roberto Gil,  ... 
doi:10.1038/sj.npp.1300970 fatcat:ikayo4dkwrdrthgopr2hltn2hi

Poster Session III

2004 Neuropsychopharmacology  
systems in those processes leading to the comorbidity of alcoholism and antisocial behaviour.  ...  Annual Meeting S185 key system involved in reward processes and the reinforcing effect of abuse drugs.  ...  and scanned serially 9 times (at baseline and up to 20 months of VNS therapy) with interleaved VNS/fMRI using a send-receive head coil.  ... 
doi:10.1038/sj.npp.1300648 fatcat:vw22deytbbeyrpwv7zwkwotqgm

SU-FF-I-79: Java-Based Plugin for Tomographic Reconstruction for SPECT Data

M Andrade, M Costa, A Marques da Silva
2006 Medical Physics (Lancaster)  
True alignment of planning and on-board image data was achieved according to a 3D point-based registration of the 6 reference BBs in the CT and CBCT images.  ...  Method and Materials: We simulated the online positioning of an anthropomorphic chest phantom with 6 noncoplanar reference BBs attached. Planning CT data of the phantom were acquired with a G.E.  ...  The GE images were acquired by a single-shot GE EPI, with TR/TE/FA =1000ms/60ms/75 °.  ... 
doi:10.1118/1.2240759 fatcat:5we2nvgwx5hrxcv2ngufce6obq

Mathematical foundations of neural systems: towards a unified description of structure, dynamics and computation

Erik Fagerholm, Robert Leech, Simon Schultz, Medical Research Council (Great Britain)
The four papers published during the course of this Ph.D. are presented, each dealing with different ways of analysing neuroimaging data in the context of graph theory (structure), percolation theory (  ...  Future directions are discussed, highlighting ways in which first steps may be taken towards the formulation of a unified mathematical foundation of neural systems.  ...  It was shown that the EEG-domain cascades map onto fMRI BOLD activation in regions associated with visual, auditory, somatosensory and motor processing.  ... 
doi:10.25560/69604 fatcat:a3arxtennrgmherkgkivja2lve

MRI Studies of Appetite Centre Function in Rodents

Nachiket Abhay Nadkarni, Amy Herlihy, Jimmy Bell
Many different regions of the brain are involved in appetite control.  ...  Most importantly, the neuroimaging analysis framework used in haemodynamic functional MRI was adapted for use with MEMRI.  ...  Electromagnetic Force EPI Echo Planar Imaging FE Frequency Encode FID Free Induction Decay fMRI Functional MRI FOV Field of View FSE Fast Spin Echo FWHM Full Width Half Maximum GE  ... 
doi:10.25560/5374 fatcat:xs5yggqsnvavnmujwgwpiszy4q

Neural computation of depth from binocular disparity

Nuno Reis Goncalves, Apollo-University Of Cambridge Repository, Apollo-University Of Cambridge Repository, Zoe Kourtzi, Andrew Welchman
Many brain regions have been implicated in stereoscopic processing, but their roles remain poorly understood. This dissertation focuses on the contributions of primary and dorsomedial visual cortex.  ...  Stereopsis is a par excellence demonstration of the computational power that neural systems can encapsulate.  ...  Finally, it is necessary to consider the possibility that clustering is enhanced by the point-spread-function (PSF) of the 3D GE-EPI sequence.  ... 
doi:10.17863/cam.27049 fatcat:jq246y4lrfgsfadwjy6qddxgmu

Abstracts of the 19th European Conference on Eye Movements 2017 [article]

Radach, Ralph; University Of Wuppertal, Vorstius, Christian; University Of Wuppertal, Hofmann (Eds.), Markus J.; University Of Wuppertal, Deubel, Heiner; University Of Munich
of the primate visual system.  ...  By measuring a shift of this distribution, recent studies used the GE to assess the presence of decision-related inputs on the motor map for eye movements.  ...  These results are in line with those of Rayner and Fischer (1996) for reading and searching in English.  ... 
doi:10.16910/jemr.10.6 fatcat:3vdhqhh3ibbjvge5pnqgljq24a
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