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Results: We present eHive, a new fault tolerant distributed processing system initially designed to support comparative genomic analysis, based on blackboard systems, network distributed autonomous agents ... In the eHive system a MySQL database serves as the central blackboard and the autonomous agent, a Perl script, queries the system and runs jobs as required. ... Acknowledgements We acknowledge the support of Guy Coates and Tim Cutts for maintaining the Ensembl compute infrastructure. ...doi:10.1186/1471-2105-11-240 pmid:20459813 pmcid:PMC2885371 fatcat:b5rulzqifzdthp5zlokvdab3ju