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GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G i subunits

L. De Vries, E. Elenko, L. Hubler, T. L. Z. Jones, M. G. Farquhar
1996 Proceedings of the National Academy of Sciences of the United States of America  
We conclude that GAIP is a membrane-anchored GAP with a cysteine string motif.  ...  Since the N terminus of GAIP contains a cysteine string motif and cysteine string proteins are heavily palmitoylated, we investigated the possibility that membraneanchored GAIP might be palmitoylated.  ...  The recent findings that cysteine string proteins are FIG. 5 . GAIP has a cysteine string motif.  ... 
doi:10.1073/pnas.93.26.15203 pmid:8986788 pmcid:PMC26381 fatcat:s74zgzer3rg5xdlktzzr4ixxbm

A new family of small, palmitoylated, membrane-associated proteins, characterized by the presence of a cysteine-rich hydrophobic motif

Jan Cools, Nicole Mentens, Peter Marynen
2001 FEBS Letters  
The CHIC proteins thus resemble the cysteine string proteins, which function in regulated exocytosis. ß  ...  Our data illustrate that cysteines in this central CHIC motif are palmitoylated and that CHIC2 is associated with vesicular structures and the plasma membrane.  ...  The high cysteine content of this motif resembles somehow the cysteine string domain of the cysteine string proteins (CSPs).  ... 
doi:10.1016/s0014-5793(01)02240-2 pmid:11257495 fatcat:5a6jryzir5drdibk7yezfpf6iu

The role of an intracellular cysteine stretch in the sorting of the type II Na/phosphate cotransporter

Gavin S. McHaffie, Chris Graham, Beate Kohl, Ursula Strunck-Warnecke, Andreas Werner
2007 Biochimica et Biophysica Acta - Biomembranes  
Our results suggest that the modified cysteine motif prevents the constructs from basolateral sorting.  ...  A C-terminal stretch of cysteine residues represents the hallmark of the NaPi-IIb isoforms. This motif is well conserved among NaPi-IIb type transporters but not found in other membrane proteins.  ...  Mutation analysis of the cysteine motif to convert the α-specific motif into the β-specific motif failed to influence trafficking.  ... 
doi:10.1016/j.bbamem.2007.05.017 pmid:17574207 fatcat:hyyefyedezdgzm3jzi5vu6swve

A Brain-specific Isoform of Small Glutamine-rich Tetratricopeptide Repeat-containing Protein Binds to Hsc70 and the Cysteine String Protein

Sönke Tobaben, Frederique Varoqueaux, Nils Brose, Bernd Stahl, Guido Meyer
2003 Journal of Biological Chemistry  
Both isoforms of SGT possess similar binding properties toward Hsc70 and cysteine string protein, a synaptic vesicle-associated J-domain-containing protein.  ...  The tetratricopeptide repeats are also necessary for binding to the cysteine string protein. However, this binding mode is distinct from the two-carboxylate clamp that is involved in Hsc70 binding.  ...  Further truncation of 6 of the cysteines of the string or all 12 central cysteines abolished binding (Fig. 5B) . These results indicate that ␤SGT binds to the cysteine string region of CSP.  ... 
doi:10.1074/jbc.m301558200 pmid:12878599 fatcat:kjbcbwttjvb3bpz43mu7caw2gy

rlk/TXKEncodes Two Forms of a Novel Cysteine String Tyrosine Kinase Activated by Src Family Kinases

Jayantha Debnath, Mario Chamorro, Michael J. Czar, Edward M. Schaeffer, Michael J. Lenardo, Harold E. Varmus, Pamela L. Schwartzberg
1999 Molecular and Cellular Biology  
The shorter, internally initiated protein species lacks the cysteine string motif and is located in the nucleus when expressed in the absence of the larger form.  ...  Unlike other members of this kinase family, Rlk lacks a pleckstrin homology (PH) domain near the amino terminus and instead contains a distinctive cysteine string motif.  ...  , including a distinct cysteine string motif, present in the larger 58-kDa isoform.  ... 
doi:10.1128/mcb.19.2.1498 pmid:9891083 pmcid:PMC116078 fatcat:gt5452dwefd7tnrp5hjl27txz4

CHIC2 (cystein-rich hydrophobic domain 2)

JL Huret
2011 Atlas of Genetics and Cytogenetics in Oncology and Haematology  
Function Member of a highly conserved family of proteins with a cysteine-rich hydrophobic (CHIC) motif; resemble the cysteine string proteins, which function in exocytosis.  ... 
doi:10.4267/2042/37839 fatcat:6uvjkx3cfjejxmgrr2ghdvmh7m

The mining of toxin-like polypeptides from EST database by single residue distribution analysis

Sergey Kozlov, Eugene Grishin
2011 BMC Genomics  
Results: Using the procedure developed, a search for amino acid sequence motifs in sea anemone polypeptides was performed, and 14 different motifs with broad and low specificity were discriminated.  ...  To search for particular protein families, the amino acid sequence motifs suitable for selective screening of nucleotide sequence databases may be used.  ...  The enrichment in cysteine residues is a characteristic feature of many natural toxins, thus making it possible to use cysteine as a key amino acid residue in data conversion.  ... 
doi:10.1186/1471-2164-12-88 pmid:21281459 pmcid:PMC3040730 fatcat:pp4lrbvr5vhcbgwk7y3xg3473y

To Find out the Essentiality of Rv0526 Gene in Virulence of Mycobacterium tube r culosis by using In silico Approaches

Laxman S Meena
2017 Open Journal of Bacteriology  
Trx are proteins that act as antioxidants by facilitating the reduction of other proteins by cysteine thiol-disulfi de exchange, and it acts by its specifi c motif Cys37-Cys40 (CXXC).  ...  Mutation in the Cystein of this motif which is a part of Trx motif can play a signifi cant role in killing the pathogenesis of mycobacterium.  ...  Figure 2 : STRING database result which shows protein-protein interaction: A STRING database server, which is used for prediction of protein-protein interactions.  ... 
doi:10.17352/ojb.000003 fatcat:qojau6xrazcqzfzeuwllsohvkm

Insights from the protein sequence and structure analysis of PgHsc70 and OsHsp70 genes

Gugulothu Baloji, Plant Molecular Biology Laboratory, Agri Biotech Foundation, Rajendra Nagar, Hyderabad (T.S) 500 030, India
2022 Bioinformation  
cysteine residues form cysteines) and 37360 and 38850 (assuming all cysteine residues are reduced) M −1 cm −1 , respectively.  ...  Using CYS_REC tool the cysteine residues in the proteins determined revealed that the protein PgHsc70 contain cysteine residues in the positions 20, 273, 319, 326, 366, 483 and 609.  ... 
doi:10.6026/97320630018088 fatcat:ubtysei4y5e3lhhr2vw77wiluu

In silico comparative analysis of tylenchid nematode pectate lyases

R.M. Moraes Filho, L.S.S. Martins
2016 Genetics and Molecular Research  
MEME revealed seven conserved motifs in the 22 evaluated sequences. The three cysteine rich motifs (Motifs 1, 4, and 6) are potentially involved in catalytic activities.  ...  Motif 4 was not present in M. incognita PL3 due the absence of two cysteines that were present in all other sequences.  ... 
doi:10.4238/gmr.15038402 pmid:27706584 fatcat:oj3vf6afvng33ojchqzgf3xt5u

Dual Role of the Cysteine-String Domain in Membrane Binding and Palmitoylation-dependent Sorting of the Molecular Chaperone Cysteine-String Protein

Jennifer Greaves, Luke H. Chamberlain, Sean Munro
2006 Molecular Biology of the Cell  
We identified a hydrophobic 31 amino acid domain, which includes the cysteine-string, as a membrane-targeting motif that associates predominantly with endoplasmic reticulum (ER) membranes.  ...  Cysteine-string protein (CSP), which is extensively palmitoylated on a "string" of 14 cysteine residues, is an example of such a protein.  ...  Thus, hydrophobic cysteine-rich domains may represent a common motif that directly associate with membranes before palmitoylation.  ... 
doi:10.1091/mbc.e06-03-0183 pmid:16943324 pmcid:PMC1635403 fatcat:rxcjyrgwpfhgnpishuwb4scda4

Bioinformatics and Multiepitope DNA Immunization to Design Rational Snake Antivenom

Simon C Wagstaff, Gavin D Laing, R. David G Theakston, Christina Papaspyridis, Robert A Harrison, Ken Winkel
2006 PLoS Medicine  
The number of ESTs in each cluster is indicated in parentheses. a2b1, a 2 b 1 integrin-binding motif in Jararhagin-C; Cys-rich, C-terminal region of the cysteine-rich domain; Dis-like, disintegrin-like  ...  I-Bi, integrin-targeting tripeptide motifs; I-Bii a 2 b 1 integrin-binding VKC-like motifs in jararhagin-C [46] ; Zn, catalytic zinc-binding motif.  ... 
doi:10.1371/journal.pmed.0030184 pmid:16737347 pmcid:PMC1472699 fatcat:xeiyp4htbvconan55jwhvi63re

Page 2722 of The Journal of Neuroscience Vol. 17, Issue 8 [page]

1997 The Journal of Neuroscience  
Csps contain a fatty acylated string of cysteine residues (Gundersen et al., 1994) and a J domain homologous to motifs in bacterial DnaJ proteins that regulate the chaperon activity of DnaK, a Hsp70-like  ...  The Journal of Neuroscience, April 15, 1997, 17(8):2722-2727 Cysteine String Proteins Associated with Secretory Granules of the Rat Neurohypophysis Sandrine Pupier,' Christian Leveque,' Beatrice Marqueze  ... 

mmsearch: a motif arrangement language and search program

T. Junier, M. Pagni, P. Bucher
2001 Bioinformatics  
This paper presents a language for describing arrangements of motifs in biological sequences, and a program that uses the language to find the arrangements in motif match databases.  ...  The program does not by itself search for the constituent motifs, and is thus independent of how they are detected, which allows it to use motif match data of various origins.  ...  The match data are converted into a string containing motif names and positions.  ... 
doi:10.1093/bioinformatics/17.12.1234 pmid:11751236 fatcat:6m6ws7fdcjdchcxvhdkzayvklm

Development of a Protein-Gene Motif Dictionary System for One-Stop Motif Analysis

Masahiro OHTOMO, Hiroaki KATO
2021 Journal of Computer Chemistry Japan -International Edition  
As a result, we discovered that zinc protease motif had co-occurrence with the cysteine switch motif.  ...  It was followed by the cysteine switch motif with a gap of 117 to 293 amino acids, however, its 3D Euclidean distance was preserved at around 12 Å.  ...  This mechanism is named cysteine switch, which is registered as cysteine switch motif in PROSITE [27] .  ... 
doi:10.2477/jccjie.2020-0008 fatcat:m3sqyps2kbdsbazwglb3yxqosq
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