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Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish

Chang-Bin Jing, Yi Chen, Mei Dong, Xiao-Lan Peng, Xiao-E Jia, Lei Gao, Ke Ma, Min Deng, Ting-Xi Liu, Leonard I. Zon, Jun Zhu, Yi Zhou (+1 others)
2013 Developmental Biology  
Positional cloning revealed that phospholipase C gamma-1 (plcg1) was mutated. Deficiency of plcg1 function specifically affected development of granulocytes, especially the maturation process.  ...  Our studies suggest that specific pathways regulate the differentiation of the hematopoietic lineages.  ...  Research Program of the Chinese Academy of Science (XDA 01010109).  ... 
doi:10.1016/j.ydbio.2012.11.032 pmid:23220656 fatcat:k4bvy6elzvg63ezrr3ue7roqgy

Phospholipase C gamma 1 (PLCG1) R707Q mutation is counterselected under targeted therapy in a patient with hepatic angiosarcoma

Hans Prenen, Dominiek Smeets, Massimiliano Mazzone, Diether Lambrechts, Xavier Sagaert, Raf Sciot, Maria Debiec-Rychter
2015 OncoTarget  
Using comprehensive molecular techniques, we explored the potential mechanisms of resistance.  ...  By low-read-depth whole-genome sequencing, the comparison of copy number aberrations (CNAs) of the primary tumor to the skin metastatic lesion that developed after progression on sunitinib, revealed highlevel  ...  ACKNOWLEDGMENTS Hans Prenen is a senior clinical investigator of the Belgian Foundation against Cancer and holder of a research grant from the Belgian Foundation against Cancer.  ... 
doi:10.18632/oncotarget.5503 pmid:26474454 pmcid:PMC4742186 fatcat:dtitrb5q7je4raiobltzfnhtzm

Alzheimer's disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

Lorenza Magno, Christian B. Lessard, Marta Martins, Verena Lang, Pedro Cruz, Yasmine Asi, Matilda Katan, Jamie Bilsland, Tammaryn Lashley, Paramita Chakrabarty, Todd E. Golde, Paul J. Whiting
2019 Alzheimer's Research & Therapy  
Amongst these, a polymorphism in phospholipase C-gamma 2 (PLCG2) P522R has been reported to be protective against LOAD.  ...  Recent Genome Wide Association Studies (GWAS) have identified novel rare coding variants in immune genes associated with late onset Alzheimer's disease (LOAD).  ...  PLCG2 belongs to the family of phospholipase C-gamma and encodes an enzyme (PLCγ2) that cleaves the membrane phospholipid PIP2 (1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate) to secondary messengers  ... 
doi:10.1186/s13195-019-0469-0 pmid:30711010 pmcid:PMC6359863 fatcat:d7izzimkefd45gxly2mgx4dndq

Alzheimer's disease Phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph [article]

Lorenza Magno, Christian B Lessard, Marta Martins, Pedro Cruz, Matilda Katan, Jamie Bilsland, Paramita Chakrabaty, Todd E Golde, Paul Whiting
2018 bioRxiv   pre-print
Amongst these, a polymorphism in Phospholipase C-gamma 2 (PLCG2) P522R, has been reported to be protective against LOAD.  ...  Functional analysis of the P522R variant in heterologous systems demonstrated a small hypermorphic effect of the mutation on enzyme function.  ...  ACKNOWLEDGMENTS We would like to thank our colleagues at the UCL ARUK-DDI for technical help and useful discussion; and Tammaryn Lashley, Queen Square UCL Brain Bank, for the provision of human tissue.  ... 
doi:10.1101/409706 fatcat:2gpec73vifctvkaeeqdr5kwaty

Restriction fragment length polymorphisms associated with immunoglobulin C gamma genes reveal linkage disequilibrium and genomic organization

N. T. Bech-Hansen, P. S. Linsley, D. W. Cox
1983 Proceedings of the National Academy of Sciences of the United States of America  
The association analysis used here should have general applicability for studying the genomic organization of other multigene families.  ...  Quantitative assessment of the degree of association between C" gene RFLPs, Gm markers, and switch region RFLPs adjacent to CA, and C., revealed that Cft, is most tightly associated with C"2 (r = 0.81  ...  Association analysis, as used in this study, has general application for the study of other multigene clusters.  ... 
doi:10.1073/pnas.80.22.6952 pmid:6316337 pmcid:PMC390104 fatcat:rno6dwo75rbbji7nhxrx574zri

small wing encodes a phospholipase C-(gamma) that acts as a negative regulator of R7 development in Drosophila

J R Thackeray, P C Gaines, P Ebert, J R Carlson
1998 Development  
Phospholipase C-(gamma) (PLC-(gamma)) is activated in many cell types following growth factor stimulation.  ...  Our understanding of the role of PLC-(gamma) in cell growth and differentiation has been severely limited by the dearth of mutations in any organism.  ...  by genomic Southern analysis.  ... 
pmid:9811587 fatcat:hczguwl6wjeqfjplzzoyu3exra

Distinct phospholipase C-gamma-dependent signaling pathways in the Drosophila eye and wing are revealed by a new small wing allele

Rishikesh Mankidy, Jeremy Hastings, Justin R Thackeray
2003 Genetics  
The Drosophila genome contains a single phospholipase C-gamma (PLC-gamma) homolog, encoded by small wing (sl), that acts as an inhibitor of receptor tyrosine kinase (RTK) signaling during photoreceptor  ...  We determined the mutant defect in all seven alleles, revealing that sl(9) is a molecular null due to a very early stop codon, while sl(7) has a missense mutation in the highly conserved Y catalytic domain  ...  We found that the molecular role in mitogenesis (Smith et al. 1994 -Eye and wing phenotypes of sl 9 homozygotes expressing various sl genomic constructs.  ... 
pmid:12807776 pmcid:PMC1462570 fatcat:r3y7j3o3rndqzkumnhvbcdf7pu

Biological and biochemical activity of v-Crk chimeras containing the SH2/SH3 regions of phosphatidylinositol-specific phospholipase C-gamma and Src

M Matsuda, C T Reichman, H Hanafusa
1992 Journal of Virology  
We studied the functional similarity of the SH2/SH3 domains by replacing those of v-Crk with those of phosphatidylinositol-specific phospholipase C-gamma, v-Src, or c-Src.  ...  Mutant viruses with Crk-SH2/SH2' domains induced tyrosine phosphorylation of cellular proteins, but mutants with phosphatidylinositol-specific phospholipase C-gamma or Src SH2/SH2' domains did not.  ...  C.T.R. was supported by training grant AI07233 from the National Institutes of Health.  ... 
pmid:1370084 pmcid:PMC238266 fatcat:dv4s4xine5dhvizot4c7dsh4ka

Biological and biochemical activity of v-Crk chimeras containing the SH2/SH3 regions of phosphatidylinositol-specific phospholipase C-gamma and Src

M Matsuda, C T Reichman, H Hanafusa
1992 Journal of Virology  
These results indicate that in the context of the P47gag-crk structure, the requirement of Crk-SH2/SH3 is more stringent for its activity to induce cell transformation than to cause phosphorylation of  ...  C.T.R. was supported by training grant AI07233 from the National Institutes of Health.  ...  Bars are prestained molecular size markers: 110, 70, and 46 kDa (from top to bottom).  ... 
doi:10.1128/jvi.66.1.115-121.1992 fatcat:fdie3jzahraubjzmgrfcwx6zga

Phospholipase C gamma and ERK1/2 Mitogen Activated Kinase Pathways are differentially modulated by Trypanosoma cruzi during tissue invasion in human placenta

Christian Castillo, Arturo Villarroel, Juan Duaso, Norbel Galanti, Gonzalo Cabrera, Juan Diego Maya, Ulrike Kemmerling
2013 Experimental parasitology  
MW: Molecular weight markers.  ...  PCR markers from Promega were employed as molecular weight standards. Statistics Results are expressed as mean ± S.D.  ... 
doi:10.1016/j.exppara.2012.10.012 pmid:23116598 fatcat:hmgowu7x65ehzmzcgnlxalfzye

Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening

Sung-Hyun Kim, Sumin Yang, Key-Hwan Lim, Euiseng Ko, Hyun-Jun Jang, Mingon Kang, Pann-Ghill Suh, Jae-Yeol Joo
2021 Proceedings of the National Academy of Sciences of the United States of America  
In this study, we discover Alzheimer's disease (AD)-specific single-nucleotide variants (SNVs) and abnormal exon splicing of phospholipase c gamma-1 (PLCγ1) gene, using genome-wide association study (GWAS  ...  A deep learning analysis, trained with human genome sequences, predicted 14 splicing sites in human PLCγ1 gene, and one of these completely matched with an SNV in exon 27 of PLCγ1 gene in an AD mouse model  ...  Therefore, identification of gene mutations in AD remains challenging, and a comparative genomics approach is required.  ... 
doi:10.1073/pnas.2011250118 pmid:33397809 fatcat:w6bqopg5n5azhawl3zjr3xebza

Duplication of the human immunoglobulin heavy chain gamma 2 gene

N T Bech-Hansen, D W Cox
1986 American Journal of Human Genetics  
Alleles of the C gamma genes in the duplication haplotype, including Gm markers of C gamma 1 and C gamma 3 and DNA polymorphisms of C psi gamma, C gamma 2, and C gamma 4, were consistent with its origin  ...  In addition, the patterns and relative intensity of BamHI fragments containing C gamma genes were those expected for genomic DNA containing three copies of C gamma 2 for every two copies of the four other  ...  Peter Linsley for many helpful discussions during the early stages of this study.  ... 
pmid:3004204 pmcid:PMC1684718 fatcat:ficko4gylfgyxpmqrf5eckejqq

c-GAMMA:Comparative Genome Analysis of Molecular Markers [chapter]

Pierre Peterlongo, Jacques Nicolas, Dominique Lavenier, Raoul Vorc'h, Joël Querellou
2009 Lecture Notes in Computer Science  
The diversity of species can now be observed in details with low cost genomic sequences produced by new generation of sequencers. A method, called c-GAMMA, is proposed.  ...  Discovery of molecular markers for efficient identification of living organisms remains a challenge of high interest.  ...  Applied on a set of height bacterial genomes (16 Mb), c-GAMMA designed primers for the detection of molecular markers in 12 hours on a standard work station, making possible the genomes differentiation  ... 
doi:10.1007/978-3-642-04031-3_23 fatcat:o4mtirxwazax5m62woev6zbfti

Genome-Wide Copy Number Variation Association Study of Atrial Fibrillation Related Thromboembolic Stroke

Chia-Shan Hsieh, Pang-Shuo Huang, Sheng-Nan Chang, Cho-Kai Wu, Juey-Jen Hwang, Eric Chuang, Chia-Ti Tsai
2019 Journal of Clinical Medicine  
Using a pathway analysis, we found deletions in GNB1, PRKCZ, and GNG7 genes related to the alpha-adrenergic receptor signaling pathway that play a major role in determining the risk of an AF-related stroke  ...  Single-nucleotide polymorphisms in several genomic regions have been found to be associated with AF.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/jcm8030332 pmid:30857284 pmcid:PMC6463198 fatcat:gcoaglfgajd35ocyee4pad3cha

Comparative Mapping of Anchor Loci from HSA19 to Cattle Chromosomes 7 and 18

Q. Gao, J. E. Womack
1997 Journal of Heredity  
Comparative genome analysis is primarily based on the mapping of Individual conserved loci in different spe- Coussens et al. (1986) cies.  ...  These genes are calreticulin (CALR), erythropoietin receptor (EPOR), proto-oncogene (JUNB and JUND), carcinoembryonic antigen (CEA), and protein kinase C, gamma subunit (PRKCG).  ... 
doi:10.1093/oxfordjournals.jhered.a023149 pmid:9419894 fatcat:jw63w66d6fagzctl6de7rhe37i
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