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Axonal Sodium-Channel Bands Shape the Response to Electric Stimulation in Retinal Ganglion Cells

Shelley I. Fried, Aaron C. W. Lasker, Neal J. Desai, Donald K. Eddington, Joseph F. Rizzo
2009 Journal of Neurophysiology  
Fried SI, Lasker ACW, Desai NJ, Eddington DK, Rizzo JF 3rd. Axonal sodium-channel bands shape the response to electric stimulation in retinal ganglion cells. .  ...  D: overlay of B and C reveals that one of the long Ankyrin G segments is coextensive with a portion of the axon. Vertical lines from C help clarify the edges of the Ankyrin G staining.  ...  Rizzo.  ... 
doi:10.1152/jn.91081.2008 pmid:19193771 pmcid:PMC4588392 fatcat:jmz3w3otrzchtdlrhjnthagxkm

Excessive Gestational Weight Gain and Postpartum Weight Retention Among Obese Women

Kimberly K. Vesco, Patricia M. Dietz, Joanne Rizzo, Victor J. Stevens, Nancy A. Perrin, Donald J. Bachman, William M. Callaghan, F Carol Bruce, Mark C. Hornbrook
2009 Obstetrics and Gynecology  
d 219 (Ϯ37) a,e,f,g 211 (Ϯ36) b,e 210 (Ϯ34) c,f 209 (Ϯ33) d,g Ͻ.001 BMI at pregnancy onset (kg/m 2 ) 39.9 (Ϯ5.7) a,b,c,d 37.2 (Ϯ5.3) a,e,f,g 35.8 (Ϯ4.7) b,e,h 35.3 (Ϯ4.6) c,f 34.8 (Ϯ4.5) d,  ...  d,e 2.8 (Ϯ15.8) c,f,g 6.3 (Ϯ17.8) a,d,g,h 13.7 (Ϯ20.9) b,e,f,h Ͻ.001 BMI, body mass index.  ... 
doi:10.1097/aog.0b013e3181baeacf pmid:20168109 fatcat:l46msrnm5zdlbldoqlxydcivh4

The Canopy Horizontal Array Turbulence Study

Edward G. Patton, Thomas W. Horst, Peter P. Sullivan, Donald H. Lenschow, Steven P. Oncley, William O. J. Brown, Sean P. Burns, Alex B. Guenther, Andreas Held, Thomas Karl, Shane D. Mayor, Luciana V. Rizzo (+12 others)
2011 Bulletin of The American Meteorological Society - (BAMS)  
O B S e rV I N G T H e C A N O PY S C A L e , OrCHArD SCALe, AND LArGer. Highresolution aerosol backscatter lidar.  ...  The towers were situated such that three middle towers (labeled B, C, and D in Fig. 4 ) were 1.72 m apart, spanning a row with the middle of these three towers (C) centered within the row.  ... 
doi:10.1175/2010bams2614.1 fatcat:aln6e5qji5cr3i2ng2wi4bm6le

Synaptic processes and immune-related pathways implicated in Tourette syndrome

Fotis Tsetsos, on behalf of the Tourette Association of America International Consortium for Genetics, Dongmei Yu, Jae Hoon Sul, Alden Y. Huang, Cornelia Illmann, Lisa Osiecki, Sabrina M. Darrow, Matthew E. Hirschtritt, Erica Greenberg, Kirsten R. Muller-Vahl, Manfred Stuhrmann (+208 others)
2021 Translational Psychiatry  
AbstractTourette syndrome (TS) is a neuropsychiatric disorder of complex genetic architecture involving multiple interacting genes. Here, we sought to elucidate the pathways that underlie the neurobiology of the disorder through genome-wide analysis. We analyzed genome-wide genotypic data of 3581 individuals with TS and 7682 ancestry-matched controls and investigated associations of TS with sets of genes that are expressed in particular cell types and operate in specific neuronal and glial
more » ... onal and glial functions. We employed a self-contained, set-based association method (SBA) as well as a competitive gene set method (MAGMA) using individual-level genotype data to perform a comprehensive investigation of the biological background of TS. Our SBA analysis identified three significant gene sets after Bonferroni correction, implicating ligand-gated ion channel signaling, lymphocytic, and cell adhesion and transsynaptic signaling processes. MAGMA analysis further supported the involvement of the cell adhesion and trans-synaptic signaling gene set. The lymphocytic gene set was driven by variants in FLT3, raising an intriguing hypothesis for the involvement of a neuroinflammatory element in TS pathogenesis. The indications of involvement of ligand-gated ion channel signaling reinforce the role of GABA in TS, while the association of cell adhesion and trans-synaptic signaling gene set provides additional support for the role of adhesion molecules in neuropsychiatric disorders. This study reinforces previous findings but also provides new insights into the neurobiology of TS.
doi:10.1038/s41398-020-01082-z pmid:33462189 fatcat:zvvzn3wbzvffnhb3yzuzh4ij34

Synaptic processes and immune-related pathways implicated in Tourette Syndrome [article]

Fotis Tsetsos, Dongmei Yu, Jae Hoon Sul, Alden Y Huang, Cornelia Illmann, Lisa Osiecki, Sabrina Darrow, Matthew E Hirschtritt, Erica Greenberg, Kirsten R Muller-Vahl, Manfred Stuhrmann, Yves Dion (+56 others)
2020 biorxiv/medrxiv   pre-print
Tourette Syndrome (TS) is a neuropsychiatric disorder of complex genetic architecture involving multiple interacting genes. Here, we sought to elucidate the pathways that underlie the neurobiology of the disorder through genome-wide analysis. We analyzed genome-wide genotypic data of 3581 individuals with Tourette Syndrome (TS) and 7682 ancestry-matched controls and investigated associations of TS with sets of genes that are expressed in particular cell types and operate in specific neuronal
more » ... pecific neuronal and glial functions. We employed a self-contained, set-based association method (SBA) as well as a competitive gene set method (MAGMA) using individual-level genotype data to perform a comprehensive investigation of the biological background of TS. Our SBA analysis identified three significant gene sets after Bonferroni correction, implicating Ligand-gated Ion Channel Signaling, Lymphocytic, and Cell Adhesion and Transsynaptic Signaling processes. MAGMA analysis further supported the involvement of the Cell Adhesion and Trans-synaptic Signaling gene set. The Lymphocytic gene set was driven by variants in FLT3, raising an intriguing hypothesis for the involvement of a neuroinflammatory element in TS pathogenesis. The indications of involvement of Ligand-gated Ion Channel Signaling reinforce the role of GABA in TS, while the association of Cell Adhesion and Transsynaptic Signaling gene set provides additional support for the role of adhesion molecules in neuropsychiatric disorders.
doi:10.1101/2020.04.24.20047845 fatcat:tntyevemwjgoziyunenlxzyhwq

Measurement of the total width, the electronic width, and the mass of theΥ(10580)resonance

B. Aubert, R. Barate, D. Boutigny, F. Couderc, J.-M. Gaillard, A. Hicheur, Y. Karyotakis, J. P. Lees, V. Tisserand, A. Zghiche, A. Palano, A. Pompili (+586 others)
2005 Physical Review D  
We measure the total width Γ_ tot to be (20.7±1.6±2.5) MeV, the electronic partial width Γ_ee = (0.321±0.017±0.029) keV and the mass M = (10579.3±0.4±1.2) MeV/c^2.  ...  Yarritu, and C. C. Young Stanford Linear Accelerator Center, Stanford, CA 94309, USA  ...  Halyo, C. Hast, T. Hryn'ova, W. R. Innes, M. H. Kelsey, P. Kim, M. L. Kocian, D. W. G. S. Leith, J. Libby, S. Luitz, V. Luth, H. L. Lynch, H. Marsiske, R. Messner, D. R. Muller, C. P. O'Grady, V. E.  ... 
doi:10.1103/physrevd.72.032005 fatcat:j2qe3zsp3bge5epqk72aqr7kxa

DSM-ffl Diagnostic and Statistical Manual of Mental Disorders (Third Edition) Chairperson, Task Force on Nomenclature and Statistics TASK FORCE ON NOMENCLATURE AND STATISTICS ADVISORY COMMITTEES ORGANIC MENTAL DISORDERS ASSEMBLY LIAISON TASK FORCE ON DSM-III BOARD OF TRUSTEES AD HOC COMMITTEE ON DSM-III

Robert Spitzer, Robert Spitzer, Morton Kramer, Sc, Nancy Andreasen, Z J Lipowski, L Robert, Arnstein, L Michael, Mavroidis, Theodore Dennis Cantwell, Millon (+266 others)
unpublished
C.  ...  C.  ...  Appendix C This page intentionally left blank C: Annotated Comparative Listing of DSM-II and DSM-III* This section lists all of the specific categories included in the previous manual (DSM-II) and the  ... 
fatcat:brnankxnzveg7az6uat6emtl5q

De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis

Sheng Wang, Jeffrey D. Mandell, Yogesh Kumar, Nawei Sun, Montana T. Morris, Juan Arbelaez, Cara Nasello, Shan Dong, Clif Duhn, Xin Zhao, Zhiyu Yang, Shanmukha S. Padmanabhuni (+140 others)
2018 Cell Reports  
R01MH092520 to Donald L.  ...  Ledbetter, C. Lord, C. Martin, D. Martin, R. Maxim, J. Miles, O. Ousley, K. Pelphrey, B. Peterson, J. Piggot, C. Saulnier, M. State, W. Stone, J. Sutcliffe, C. Walsh, Z. Warren, and E. Wijsman).  ... 
doi:10.1016/j.celrep.2018.08.082 pmid:30257206 pmcid:PMC6475626 fatcat:cqkccsrqbfcbfczg5snh3ywpqy

The BaBar detector: Upgrades, operation and performance

B. Aubert, R. Barate, D. Boutigny, F. Couderc, P. del Amo Sanchez, J.-M. Gaillard, A. Hicheur, Y. Karyotakis, J.P. Lees, V. Poireau, X. Prudent, P. Robbe (+1072 others)
2013 Nuclear Instruments and Methods in Physics Research Section A : Accelerators, Spectrometers, Detectors and Associated Equipment  
C. Schofieldau , R. J. Sloaneau , C. Touramanisau , D. E. Azzopardiav , G. Bellodiav , A. J. Bevanav , C. K. Clarkeav , C. M. Cormackav , F. Di Lodovicoav , P. Dixonav , K. A. Georgeav , W.  ...  Serraca , C. Voenaca , C. Büngercc , S. Christcc , T. Hartmanncc , T. Leddigcc , H. Schrödercc , G. Wagnercc , R. Waldicc , T. Adyecd , M. Blycd , C. Brewcd , C. Condurachecd , N. De Grootcd , B.  ... 
doi:10.1016/j.nima.2013.05.107 fatcat:4x6tetnxgrfnfjhrnty3ebi65i

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Phil H. Lee, Verneri Anttila, Hyejung Won, Yen-Chen A. Feng, Jacob Rosenthal, Zhaozhong Zhu, Elliot M. Tucker-Drob, Michel G. Nivard, Andrew D. Grotzinger, Danielle Posthuma, Meg M.-J. Wang, Dongmei Yu (+594 others)
2019 Cell  
Two Hi-C datasets originated from the human brain (fetal brain Hi-C (Won et al., 2016) and adult brain Hi-C ) were used to map credible SNPs to remotely interacting genes as previously described .  ...  (C) rs117956829 on 11q14.3; and (D) rs10265001 on 7q34. Figure 4 4 Figure 4.  ... 
doi:10.1016/j.cell.2019.11.020 pmid:31835028 pmcid:PMC7077032 fatcat:ic7czxtq6zbz7djatpk7xvnixq