6 Hits in 0.53 sec


Laura Banks, Lorna Bigsby, Maureen Conroyd, Cynthia First, Celia Griffin, Billie Grissom, Brad Lancaster, Deb Millar, Anne Perry, Kevin Scudder, Jeff Shushan
2011 Family Court Review  
This article describes the development of a practice group based on a hunter-gatherer model, with the mission of providing high quality collaborative divorce services, with an emphasis on protecting children and divorcing partners, and expanding access to middle-and lower-income families. The practice group professional disciplines include law, mental health divorce coaching, co-parent coaching, financial analysis, and case administration. These professionals have collectively associated their
more » ... y associated their individual practices to address challenges facing their collaborative practices. With common purpose, the practice group builds skills, generates client base, nurtures trust, and lays a common knowledge base. Collaborative divorce teams formed from its members serve divorcing families with efficient, cost-conscious, interest-based negotiation processes that protect children and help parties productively move on with their lives. WALKING DOROBO Collaborative professionals gather. They tend to be "people" people. Collaborators like meeting. Collaborative practice groups 2 emerge locally, most often with geographical roots, and then flower into larger aggregations as county, state, and international organizations. 3 Our individual collaborative skills have been deeply enriched by local practice groups. Nevertheless, we felt something missing in ourselves, and in our collaborative work.f cre_1368 249.. 256 The professionals of Cypress Collaborative Solutions, before we became Cypress, enthusiastically collaborated for divorce clients, helping them transition from distressed to binuclear families. 4 We advanced our collaborative training. We hoped that more collaborative casework would follow. And it did. But none among us engaged the number of collaborative cases desired or felt the public, judiciary, or attorney bar was being adequately educated about the collaborative process. We hoped that our efforts, combined with the efforts of others in our collaborative community, would mainstream collaboration, making it as well known and accepted as mediation. We hoped the public would come to consider collaboration a serious alternative to litigation. And we hoped that our services would prove more transformative for our collaborating clients. Our individual efforts proved insufficient. We paused and took stock. We scrutinized our professional practice model. We asked, how can we better carry the collaborative message to the public? We determined that we collaborated for others, but resisted fully collaborating with one another. We negotiated parenting plans and asset divisions of others, but resisted collaborating our business practices, personal quirks, and visions of the future. When first forming, we had difficulty making decisions and reaching agreement on Cypress's organizational structure. We had differing visions of the meaning of collaboration. Emotions often ran high. We suffered some strife and interpersonal rifts. We labored over whether there should be a period at the end of our logo tag line. Pauline Tesler had warned and challenged us: collaborators resist collaborating with one another. 5 The Cypress structure is our attempt to address the constellation of challenges we unearthed in ourselves and in our separate practices. Through the Cypress vision and
doi:10.1111/j.1744-1617.2011.01368.x fatcat:srhjps6gezckbfzhf3fhq4chv4

Third Report on Chicken Genes and Chromosomes 2015

Michael Schmid, Jacqueline Smith, David W. Burt, Bronwen L. Aken, Parker B. Antin, Alan L. Archibald, Chris Ashwell, Perry J. Blackshear, Clarissa Boschiero, C. Titus Brown, Shane C. Burgess, Hans H. Cheng (+92 others)
2015 Cytogenetic and Genome Research  
Griffin et al., 2007 Griffin et al., , 2008 Skinner et al., 2009; Völker et al., 2010] with less attention to its functional relevance.  ...  Griffin, M.N. Romanov, R. O'Connor, K.E. Fowler, and D.M.  ... 
doi:10.1159/000430927 pmid:26282327 pmcid:PMC5120589 fatcat:66epxqpbhrdxpno7n5or4gnbzq

Corrigendum: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Benjamin F Voight, Laura J Scott, Valgerdur Steinthorsdottir, Andrew P Morris, Christian Dina, Ryan P Welch, Eleftheria Zeggini, Cornelia Huth, Yurii S Aulchenko, Gudmar Thorleifsson, Laura J McCulloch, Teresa Ferreira (+146 others)
2011 Nature Genetics  
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis (vol 42, pg 579, 2010) Citation for published version:
doi:10.1038/ng0411-388b fatcat:dhxfolw5ajdoddy4s3wcdbznoq

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Benjamin F Voight, Laura J Scott, Valgerdur Steinthorsdottir, Andrew P Morris, Christian Dina, Ryan P Welch, Eleftheria Zeggini, Cornelia Huth, Yurii S Aulchenko, Gudmar Thorleifsson, Laura J McCulloch, Teresa Ferreira (+146 others)
2010 Nature Genetics  
By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P < 5 × 10 −8 . These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of overlap
more » ... nce of overlap between loci implicated in monogenic and multifactorial forms of diabetes (at HNF1A). The identified loci affect both beta-cell function and insulin action, and, overall, T2D association signals show evidence of enrichment for genes involved in cell cycle regulation. We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis A full list of author affiliations appears at the end of the paper.
doi:10.1038/ng.609 pmid:20581827 pmcid:PMC3080658 fatcat:wimog5e53nchxov6yaii6u57dy

Leveraging Cross-Species Transcription Factor Binding Site Patterns: From Diabetes Risk Loci to Disease Mechanisms

Melina Claussnitzer, Simon N. Dankel, Bernward Klocke, Harald Grallert, Viktoria Glunk, Tea Berulava, Heekyoung Lee, Nikolay Oskolkov, Joao Fadista, Kerstin Ehlers, Simone Wahl, Christoph Hoffmann (+183 others)
2014 Cell  
Genome-wide association studies have revealed numerous risk loci associated with diverse diseases. However, identification of disease-causing variants within association loci remains a major challenge. Divergence in gene expression due to cis-regulatory variants in noncoding regions is central to disease susceptibility. We show that integrative computational analysis of phylogenetic conservation with a complexity assessment of co-occurring transcription factor binding sites (TFBS) can identify
more » ... TFBS) can identify cis-regulatory variants and elucidate their mechanistic role in disease. Analysis of established type 2 diabetes risk loci revealed a striking clustering of distinct homeobox TFBS. We identified the PRRX1 homeobox factor as a repressor of PPARG2 expression in adipose cells and demonstrate its adverse effect on lipid metabolism and systemic insulin sensitivity, dependent on the rs4684847 risk allele that triggers PRRX1 binding. Thus, cross-species conservation analysis at the level of co-occurring TFBS provides a valuable contribution to the translation of genetic association signals to disease-related molecular mechanisms.
doi:10.1016/j.cell.2013.10.058 pmid:24439387 pmcid:PMC7116609 fatcat:7f3fxtryrrhxznlgprhgegkxc4

Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials

Alex S. Willoughby, Gui-shuang Ying, Cynthia A. Toth, Maureen G. Maguire, Russell E. Burns, Juan E. Grunwald, Ebenezer Daniel, Glenn J. Jaffe, David F. Williams, Sara Beardsley, Steven Bennett, Herbert Cantrill (+890 others)
2015 Ophthalmology (Rochester, Minn.)  
Objective-To evaluate the association of subretinal hyper-reflective material (SHRM) with visual acuity (VA), geographic atrophy (GA) and scar in the Comparison of Age related Macular Degeneration Treatments Trials (CATT) Design-Prospective cohort study within a randomized clinical trial. Participants-The 1185 participants in CATT. Methods-Participants were randomly assigned to ranibizumab or bevacizumab treatment monthly or as-needed. Masked readers graded scar and GA on fundus photography and
more » ... dus photography and fluorescein angiography images, SHRM on time domain (TD) and spectral domain (SD) optical coherence tomography (OCT) throughout 104 weeks. Measurements of SHRM height and width in the fovea, within the center 1mm 2 , or outside the center 1mm 2 were obtained on SD-OCT images at 56 (n=76) and 104 (n=66) weeks. VA was measured by certified examiners. Main Outcome Measures-SHRM presence, location and size, and associations with VA, scar, and GA. Results-Among all CATT participants, the percentage with SHRM at enrollment was 77%, decreasing to 68% at 4 weeks after treatment and 54% at 104 weeks. At 104 weeks, scar was present more often in eyes with persistent SHRM than eyes with SHRM that resolved (64% vs. 31%; p<0.0001). Among eyes with detailed evaluation of SHRM at weeks 56 (n=76) and 104 (n=66), mean [SE] VA letter score was 73.5 [2.8], 73.1 [3.4], 65.3 [3.5], and 63.9 [3.7] when SHRM was absent, present outside the central 1mm 2 , present within the central 1mm 2 but not the foveal center, or present at the foveal center (p=0.02). SHRM was present at the foveal center in 43 (30%), within the central 1mm 2 in 21 (15%) and outside the central 1mm 2 in 19 (13%). When SHRM was present, the median maximum height in microns under the fovea, within the central 1 mm 2 including the fovea and anywhere within the scan was 86; 120; and 122, respectively. VA was decreased with greater SHRM height and width (p<0.05). Conclusions-SHRM is common in eyes with NVAMD and often persists after anti-VEGF treatment. At 2 years, eyes with scar were more likely to have SHRM than other eyes. Greater SHRM height and width were associated with worse VA. SHRM is an important morphological biomarker in eyes with NVAMD.
doi:10.1016/j.ophtha.2015.05.042 pmid:26143666 pmcid:PMC4549177 fatcat:yhsawzf3mzhi3jetnddebfx5mi