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Hoyeraal-Hreidarsson Syndrome due to PARN Mutations: Fourteen Years of Follow-Up

Ashley M. Burris, Bari J. Ballew, Joshua B. Kentosh, Clesson E. Turner, Scott A. Norton, Neelam Giri, Blanche P. Alter, Anandani Nellan, Christopher Gamper, Kip R. Hartman, Sharon A. Savage, Sara Bass (+39 others)
2016 Pediatric Neurology  
Introduction-Hoyeraal-Hreidarsson syndrome is a dyskeratosis congenita-related telomere biology disorder that presents in infancy with intrauterine growth retardation immunodeficiency, and cerebellar hypoplasia in addition to the triad of nail dysplasia, skin pigmentation, and oral leukoplakia. Patients with Hoyeraal-Hreidarsson syndrome often develop bone marrow failure in early childhood. Germline mutations in DKC1, TERT, TINF2, RTEL1, ACD, and PARN cause about 60% of Hoyeraal-Hreidarsson
more » ... aal-Hreidarsson syndrome cases.
doi:10.1016/j.pediatrneurol.2015.12.005 pmid:26810774 pmcid:PMC4789174 fatcat:j2l7vxbv6ra3rf4k2upmb54foi

The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project

Lawrence N. Hudson, Tim Newbold, Sara Contu, Samantha L. L. Hill, Igor Lysenko, Adriana De Palma, Helen R. P. Phillips, Tamera I. Alhusseini, Felicity E. Bedford, Dominic J. Bennett, Hollie Booth, Victoria J. Burton (+503 others)
2016 Ecology and Evolution  
Buscardo et al. (2008), 3 Christensen and Heilmann-Clausen (2009), 4 Domínguez, Bahamonde, and Muñoz-Escobar (2012), 5 López-Quintero, Straatsma, Franco-Molano, and Boekhout (2012), 6 Nöske et al. (2008), 7 Norton  ...  We thank Technical Solutions and Informatics staff at the Natural History Museum, London, especially Srinivas Patlola, Simon Rycroft, Ben Scott and Chris Sleep. CONFLICT OF INTEREST None declared.  ... 
doi:10.1002/ece3.2579 pmid:28070282 pmcid:PMC5215197 fatcat:pid37i2ixvdzxjmc6mds4v424i

The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project

Lawrence Hudson, Tim Newbold, Sara Contu, Samantha Hill, Igor Lysenko, Adriana De Palma, Helen Phillips, Tamera Alhusseini, Felicity Bedford, Dominic Bennett, Hollie Booth, Victoria Burton (+503 others)
2017 Ecology and Evolution   unpublished
OATAO is an open access repository that collects the work of Toulouse researchers and makes it freely available over the web where possible.
fatcat:ub7lgf5qgrfz7j6wdqwbod6kjy

A Note of Thanks!

Charles Doris, Adams Jacob, Hayya Adler, James, Andrea Aldrich, Ann Allen, David Allen, Durward Allen, Allen Frances, Allen Robert, Alsobrook Lota, Karen Mark (+827 others)
2009 unpublished
displaying the free-standing photo of Leslie Stringfellow purchased at an auction that began his quest to discover the story of Stringfellow's life, and afterlife.
fatcat:o2cyugvzfvdh7cszlzylsas6bm

The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project

Lawrence N. Hudson, Tim Newbold, Sara Contu, Samantha L. L. Hill, Igor Lysenko, Adriana De Palma, Helen R. P. Phillips, Tamera I. Alhusseini, Felicity E. Bedford, Dominic J. Bennett, Hollie Booth, Victoria J. Burton (+503 others)
2016
Buscardo et al. (2008), 3 Christensen and Heilmann-Clausen (2009), 4 Domínguez, Bahamonde, and Muñoz-Escobar (2012), 5 López-Quintero, Straatsma, Franco-Molano, and Boekhout (2012), 6 Nöske et al. (2008), 7 Norton  ...  We thank Technical Solutions and Informatics staff at the Natural History Museum, London, especially Srinivas Patlola, Simon Rycroft, Ben Scott and Chris Sleep. CONFLICT OF INTEREST None declared.  ... 
doi:10.24451/arbor.8238 fatcat:lz3twgtan5d5xkt52hjldbfdbm

Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial

Martin Dennis, Gillian Mead, John Forbes, Catriona Graham, Maree Hackett, Graeme J Hankey, Allan House, Stephanie Lewis, Erik Lundström, Peter Sandercock, Karen Innes, Carol Williams (+1285 others)
2019 The Lancet  
Results of small trials indicate that fluoxetine might improve functional outcomes after stroke. The FOCUS trial aimed to provide a precise estimate of these effects.
doi:10.1016/s0140-6736(18)32823-x pmid:30528472 pmcid:PMC6336936 fatcat:ltls3mo675h6nhqbsxq46tcfpi

The surgical safety checklist and patient outcomes after surgery: a prospective observational cohort study, systematic review and meta-analysis

T.E.F. Abbott, T. Ahmad, M.K. Phull, A.J. Fowler, R. Hewson, B.M. Biccard, M.S. Chew, M. Gillies, R.M. Pearse, Rupert M. Pearse, Scott Beattie, Pierre-Alain Clavien (+2645 others)
2018 British Journal of Anaesthesia  
The surgical safety checklist is widely used to improve the quality of perioperative care. However, clinicians continue to debate the clinical effectiveness of this tool. Methods Prospective analysis of data from the International Surgical Outcomes Study (ISOS), an international observational study of elective in-patient surgery, accompanied by a systematic review and meta-analysis of published literature. The exposure was surgical safety checklist use. The primary outcome was in-hospital
more » ... s in-hospital mortality and the secondary outcome was postoperative complications. In the ISOS cohort, a multivariable multilevel generalized linear model was used to test associations. To further contextualise these findings, we included the results from the ISOS cohort in a meta-analysis. Results are reported as odds ratios (OR) with 95% confidence intervals. Results We included 44 814 patients from 497 hospitals in 27 countries in the ISOS analysis. There were 40 245 (89.8%) patients exposed to the checklist, whilst 7508 (16.8%) sustained 1 postoperative complications and 207 (0.5%) died before hospital discharge. Checklist exposure was associated with reduced mortality [odds ratio (OR) 0.49 (0.32-0.77); P<0.01], but no difference in complication rates [OR 1.02 (0.88-1.19); P=0.75]. In a systematic review, we screened 3732 records and identified 11 eligible studies of 453 292 patients including the ISOS cohort. Checklist exposure was associated with both reduced postoperative mortality [OR 0.75 (0.62-0.92); P<0.01; I2=87%] and reduced complication rates [OR 0.73 (0.61-0.88); P<0.01; I2=89%). Conclusions Patients exposed to a surgical safety checklist experience better postoperative outcomes, but this could simply reflect wider quality of care in hospitals where checklist use is routine.
doi:10.1016/j.bja.2017.08.002 pmid:29397122 fatcat:ot6rc4jhjbfefcnttjkmap2rke