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GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer's Disease

Carlos Cruchaga, John S.K. Kauwe, Oscar Harari, Sheng Chih Jin, Yefei Cai, Celeste M. Karch, Bruno A. Benitez, Amanda T. Jeng, Tara Skorupa, David Carrell, Sarah Bertelsen, Matthew Bailey (+25 others)
2013 Neuron  
Cerebrospinal fluid (CSF) tau, tau phosphorylated at threonine 181 (ptau), and Ab 42 are established biomarkers for Alzheimer's disease (AD) and have been used as quantitative traits for genetic analyses. We performed the largest genome-wide association study for cerebrospinal fluid (CSF) tau/ptau levels published to date (n = 1,269), identifying three genome-wide significant loci for CSF tau and ptau: rs9877502 (p = 4.89 3 10 À9 for tau) located at 3q28 between GEMC1 and OSTN, rs514716 (p =
more » ... 7 3 10 À8 and p = 3.22 3 10 À9 for tau and ptau, respectively), located at 9p24.2 within GLIS3 and rs6922617 (p = 3.58 3 10 À8 for CSF ptau) at 6p21.1 within the TREM gene cluster, a region recently
doi:10.1016/j.neuron.2013.02.026 pmid:23562540 pmcid:PMC3664945 fatcat:pzj2jwrrxfa3hcu3nwa5atn454

Current directions in tau research: Highlights from Tau 2020

Claire Sexton, Heather Snyder, Dirk Beher, Adam L. Boxer, Pat Brannelly, Jean‐Pierre Brion, Luc Buée, Angela M. Cacace, Gaël Chételat, Martin Citron, Sarah L. DeVos, Kristophe Diaz (+23 others)
2021 Alzheimer's & Dementia  
A recent project co-led by Celeste Karch, Alison Goate, and Sally Temple, involving the collection of fibroblasts, iPSCs, and neural precursor cells from individuals with a range of primary tauopathies  ... 
doi:10.1002/alz.12452 pmid:34581500 fatcat:ldn724dibfbcvg3b3ycyifsnwy

Global, regional, and national mortality among young people aged 10–24 years, 1950–2019: a systematic analysis for the Global Burden of Disease Study 2019

Joseph L Ward, Peter S Azzopardi, Kate Louise Francis, John S Santelli, Vegard Skirbekk, Susan M Sawyer, Nicholas J Kassebaum, Ali H Mokdad, Simon I Hay, Foad Abd-Allah, Amir Abdoli, Mohammad Abdollahi (+637 others)
2021 The Lancet  
M Ausloos reports grants or contracts from Romanian National Authority for Scientific Research and Innovation, CNDS-UEFISCDI, project number PN-III-P4-ID-PCCF-2016-0084, outside the submitted work.  ... 
doi:10.1016/s0140-6736(21)01546-4 pmid:34755628 pmcid:PMC8576274 fatcat:6rrienkrojcp5hcj5reouabehy

Five insights from the Global Burden of Disease Study 2019

Christopher J L Murray, Cristiana Abbafati, Kaja M Abbas, Mohammad Abbasi, Mohsen Abbasi-Kangevari, Foad Abd-Allah, Mohammad Abdollahi, Parisa Abedi, Aidin Abedi, Hassan Abolhassani, Victor Aboyans, Lucas Guimarães Abreu (+853 others)
2020 The Lancet  
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually
more » ... e and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3·5 billion estimates of health outcome and health system measures of interest for global, national, and subnational policy dialogue. All GBD estimates are publicly available and adhere to the Guidelines on Accurate and Transparent Health Estimate Reporting. From this vast amount of information, five key insights that are important for health, social, and economic development strategies have been distilled. These insights are subject to the many limitations outlined in each of the component GBD capstone papers.
doi:10.1016/s0140-6736(20)31404-5 pmid:33069324 pmcid:PMC7116361 fatcat:46cyf7zbhvhzhknmgtrdrzksci

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Theo Vos, Stephen S Lim, Cristiana Abbafati, Kaja M Abbas, Mohammad Abbasi, Mitra Abbasifard, Mohsen Abbasi-Kangevari, Hedayat Abbastabar, Foad Abd-Allah, Ahmed Abdelalim, Mohammad Abdollahi, Ibrahim Abdollahpour (+1018 others)
2020 The Lancet  
L M Haile reports personal fees from WHO, outside of the submitted work. S M S Islam reports grants from National Heart Foundation of Australia and Deakin University, during the conduct of the study.  ...  M Moradi-Lakeh reports personal fees from Novartis, outside of the submitted work. J F Mosser reports grants from the Bill & Melinda Gates Foundation, during the conduct of the study.  ...  M G Shrime reports grants from Damon Runyon Cancer Research Foundation and Mercy Ships, outside of the submitted work.  ... 
doi:10.1016/s0140-6736(20)30925-9 pmid:33069326 pmcid:PMC7567026 fatcat:ed2mr34cvjal5iuotty5c26to4

Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019

Haidong Wang, Kaja M Abbas, Mitra Abbasifard, Mohsen Abbasi-Kangevari, Hedayat Abbastabar, Foad Abd-Allah, Ahmed Abdelalim, Hassan Abolhassani, Lucas Guimarães Abreu, Michael R M Abrigo, Abdelrahman I Abushouk, Maryam Adabi (+716 others)
2020 The Lancet  
Hosna Janjani, Ravi Jha, Vivekanand Jha, John Ji, Morgado-Da-Costa Joana, Jost Jonas, Farahnaz Joukar, Jacek Jozwiak, Mikk Jürisson, Zubair Kabir, Leila Kalankesh, Tanuj Kanchan, Neeti Kapoor, André Karch  ...  Hiroyasu Iso, Olusanya Jacob, Kathryn Jacobsen, Ensiyeh Jenabi, Ravi Jha, Vivekanand Jha, John Ji, Morgado-Da-Costa Joana, Jost Jonas, Jacek Jozwiak, Mikk Jürisson, Hamed Kalani, Neeti Kapoor, André Karch  ...  Then the posterior distribution, 𝑓 ̃, is: 𝑓 ̃𝑐 | 𝑑𝑎𝑡𝑎 ∼ 𝐺𝑃(𝑀 ̃, 𝐶 ̃) 𝑀 ̃(𝑡) = 𝑀(𝑡) + 𝐶(𝑡, 𝑜)[𝐶(𝑜, 𝑜) + 𝑉] −1 (𝑓(𝑜) − 𝑀(𝑜)) 𝐶 ̃(𝑡 𝑖 , 𝑡 𝑗 ) = 𝐶(𝑡 𝑖 , 𝑡 𝑗 ) − 𝐶(𝑡 𝑖  ... 
doi:10.1016/s0140-6736(20)30977-6 pmid:33069325 pmcid:PMC7566045 fatcat:3s6sgltnabbnhiq7jab7tyk6zu

Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Christopher J L Murray, Aleksandr Y Aravkin, Peng Zheng, Cristiana Abbafati, Kaja M Abbas, Mohsen Abbasi-Kangevari, Foad Abd-Allah, Ahmed Abdelalim, Mohammad Abdollahi, Ibrahim Abdollahpour, Kedir Hussein Abegaz, Hassan Abolhassani (+928 others)
2020 The Lancet  
This includes outcomes linked to low birthweight and short gestational age as intermediate outcomes linked to particulate matter with a diameter smaller than 2•5 μm (PM 2•5 ), which has increased the burden  ...  intake will not only be important for human health but has important ramifications for environmental sustainability. 36 he two types of exposure to particulate matter with a diameter of less than 2•5 μm  ... 
doi:10.1016/s0140-6736(20)30752-2 pmid:33069327 pmcid:PMC7566194 fatcat:wtbkjwyugfhglhuphdlczi5fty

Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019

Katherine R Paulson, Aruna M Kamath, Tahiya Alam, Kelly Bienhoff, Gdiom Gebreheat Abady, Jaffar Abbas, Mohsen Abbasi-Kangevari, Hedayat Abbastabar, Foad Abd-Allah, Sherief M Abd-Elsalam, Amir Abdoli, Aidin Abedi (+727 others)
2021 The Lancet  
of Health Policy and Management (S Nomura PhD), Keio University, Tokyo, Japan; Department of Global Health Policy (S Nomura PhD), University of Tokyo, Tokyo, Japan; Department of Gastroenterology (N M  ... 
doi:10.1016/s0140-6736(21)01207-1 pmid:34416195 pmcid:PMC8429803 fatcat:rt7wpc2v5jd4faza7bbiwixyyu